Wy 49051

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Wy 49051 是一种口服活性的 H1 受体拮抗剂（IC50 为 44 nM）。

Wy 49051 is an orally active antagonist of H1 receptor(IC50 of 44 nM).(In Vitro):Wy 49051 showed a great inhibitory effect on H1. At a concentration of 100 nM, it produced 92% inhibition of histamine-induced guinea pig ileal contraction. Wy 49051 is the most effective compound, with 700 times the potency of astemizole and 470 times the potency of hydroquinone. Wy 49051 also has high affinity for α1 receptor with IC50 of 8 nM.(In Vivo):Wy 49051 shows against histamine-induced lethality in the guinea pig(ED50 of 1.91 mg/kg by po, 0.70 mg/kg by ip, and 0.01 mg/kg by iv). The duration of action of 24 is also favorable since there is no decrease in oral efficacy up to 18 h posttreatment.

Wy 49051 shows great inhibitory effect on H1, producing 92% inhibition of the histamine-induced contraction of the guinea pig ileum at a concentration 100 nM. Wy 49051 is the most potent compound with 700 times the potency of astemazole, 470 times the potency of chlorpheniramine. Wy 49051 also has high affinity for α1 receptor with IC50 of 8 nM.

Wy 49051 shows potent activity against histamine-induced lethality in the guinea pig, with ED50 of 1.91 mg/kg by po, 0.70 mg/kg by ip, and 0.01 mg/kg by iv. The duration of action of 24 is also favorable since there is no decrease in oral efficacy up to 18 h posttreatment.

Wy-49051

Angiogenesis

ALK

Arenavirus

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113418-56-7

487.604

C28H33N5O3

>98% (HPLC)

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Cn1c2ncn(CCCN3CCC(CC3)OC(c3ccccc3)c3ccccc3)c2c(=O)n(C)c1=O

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(-20℃)

With Ice Pack

≥ 2 years