NSC 145366 ( NSC145366 )

产品货号. M10250 CAS No. 1052515-37-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

NSC 145366
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

NSC 145366 是一种新型变构 Hsp90 CTD（C 末端结构域）抑制剂。
产品描述

NSC 145366 is a novel, allosteric Hsp90 CTD (C-terminal domain) inhibitor, exhibits anti-proliferative activity in tumor cell lines with GI50 of 0.2-1.9 uM; increases Hsp90 oligomerization resulting in allosteric inhibition of NTD ATPase activity (IC50=119 uM), but does not compete with NTD or CTD-ATP binding; causes selective client protein downregulation including AR and BRCA1 but without a heat shock response in LNCaP prostate tumor cells.
体外实验

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体内实验

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同义词

NSC145366
通路

Cytoskeleton/Cell Adhesion Molecules
靶点

HSP
受体

HSP
研究领域

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适应症

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CAS Number

1052515-37-3
分子量

635.371
分子式

C37H63ClN2O4
纯度

>98% (HPLC)
溶解度

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SMILES

CC(C1=CC=C(OCC(O)CNC(C)(C)CC(C)(C)C)C=C1)(C2=CC=C(OCC(O)CNC(C)(C)CC(C)(C)C)C=C2)C.[H]Cl.[H]Cl
化学全称

1-[4-[2-[4-[2-hydroxy-3-(2,4,4-trimethylpentan-2-ylamino)propoxy]phenyl]propan-2-yl]phenoxy]-3-(2,4,4-trimethylpentan-2-ylamino)propan-2-ol hydrochloride

1. Thomas FM, et al. SLAS Discov. 2017 Jul;22(6):706-719. 2. Goode KM, et al. Biochim Biophys Acta. 2017 Aug;1861(8):1992-2006.

计算器

产品手册

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