AVN-101

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种高效、口服生物利用度、BBB 渗透性 5-HT7 受体拮抗剂，Ki 为 153 pM，对 5-HT6、5-HT2A 和 5HT-2C 的效力略低（Ki = 1.2-2.0 nM）。

A higly potent, orally bioavailable, BBB permeable 5-HT7 receptor antagonist with Ki of 153 pM, with slightly lesser potency toward 5-HT6, 5-HT2A and 5HT-2C (Ki?=?1.2-2.0 ?nM); also exhibits a rather high affinity toward histamine H1 (Ki?=?0.58?nM) and adrenergic α2A, α2B, and α2C (Ki?=?0.41-3.6?nM) receptors; demonstrates reasonable anxiolytic and anti-depressive activities in animal models of CNS diseases with low safety concerns.Anxiety Phase 2 Clinical.

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AVN101

GPCR/G Protein

5-HT Receptor

5-HT Receptor

Neurological Disease

Anxiety

1025725-91-0

304.437

C21H24N2

>98% (HPLC)

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CC1=CC2=C(C=C1)N(C3=C2CN(CC3)C)CCC4=CC=CC=C4

2,8-dimethyl-5-phenethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

(-20℃)

With Ice Pack

≥ 2 years