Glyburide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

格列本脲（格列本脲）是一种磺酰脲类化合物，可调节胰岛素的产生。

Glibenclamide(Glyburide) is a sulfonylurea compound that modulates insulin production. (In Vitro):Glibenclamide (Brown adipocytes; 10 μΜ; 1 day) has no effect on adipocyte differentiation. Glibenclamide (Ucp1-2A-GFP brown adipocyte) significantly increases UCP1 expression. Glibenclamide directly binds and blocks the SUR1 subunits of ATP-dependent potassium channels (KATP) and consequently increases insulin secretion from the pancreatic β cells. Glibenclamide interferes with mitochondrial bioenergy by permeating mitochondrial intima with Cl- and promoting mitochondrial net Cl-/K+ cotransport. Glibenclamide induced autophagy inhibits its insulin secretion-improving function in β cells.(In Vivo):Glibenclamide (2 mg/kg; p.o.) increases of insulin release and rapid drop of blood glucose level.Glibenclamide (50 μg/kg; p.o.) does not cause significant change, such as body weight or body composition.

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Animal Model:Mice Dosage:2 mg/kg Administration:P.o.Result:Increased of insulin release and rapid drop of blood glucose level.

Glyburide | Glibenclamide | Micronase | Diabeta | HB-420 | HB419 | Maninil | Neogluconin

Cell Cycle/DNA Damage

Potassium Channel

Bile salt export pump| Potassium Channel

Metabolic Disease

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10238-21-8

494.01

C23H28ClN3O5S

>98% (HPLC)

DMSO: 99mg/ml(200.4 mM);Water: <1mg/ml;Ethanol: <1mg/ml

COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3

5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide

(-20℃)

With Ice Pack

≥ 2 years