M-110

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

M-110 是一种有效的、选择性的 PIM 激酶家族抑制剂，优先考虑 PIM-3，对 PIM3、PIM1 和 PIM2 的 IC50 值分别为 0.047、2.5 和 2.5 uM。

M-110 is a potent, selective inhibitor of PIM kinase family with preference for PIM-3 with IC50 of 0.047, 2.5 and 2.5 uM for PIM3, PIM1 and PIM2, respectively; dispplays excellent selectivity in a panel of 261 kinases; inhibits the growth of DU-145 cells with IC50 of 0.9 uM, significantly reduces pSTAT3(Tyr705) expression without affecting the expression of STAT3, also attenuates the IL-6-induced increase in pSTAT3(Tyr705), shows no effect on phosphorylation of STAT5 on Tyr694 in 22Rv1 cells.

M-110 (0.01-10 μM; 72 hours) inhibiting the growth of DU-145 cells with an IC50?value of 0.9 μM. M-110 has no activity on normal human peripheral blood mononuclear cells up to 40 μM.M-110 (10 μM; 18 hours) inhibits STAT3 Tyr705?phosphorylation.M-110 inhibits the expression of active STAT3 through inhibition of PIM-3. M-110 also inhibits the proliferation of 22Rv1, PC3, and SW480 cells, with IC50?values of 0.6 to 0.8 μM.Cell Viability Assay Cell Line:DU-145 cells Concentration:0.01, 0.1, 1, 10 μM Incubation Time:72 hours Result:Inhibiting the growth of DU-145 cells with an IC50?value of 0.9 μM.Western Blot Analysis Cell Line:DU-145 cells Concentration:10 μM Incubation Time:18 hours Result:Reduced the expression of p-STAT3 Tyr705?to 23.5%, compared with untreated cells without affecting the expression of STAT3.?

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M110

JAK/STAT Signaling

Pim

Pim

Cancer

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1395048-49-3

445.9424

C22H28ClN5O3

>98% (HPLC)

10 mM in DMSO

O=C(N/N=C(C1=CC=C(Cl)C=C1O)\CC)C2=CC=NC(NCCCN3CCOCC3)=C2

4-Pyridinecarboxylic acid, 2-[[3-(4-morpholinyl)propyl]amino]-, 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide

(-20℃)

With Ice Pack

≥ 2 years