Lumateperone
CAS No. 313368-91-1
Lumateperone ( ITI-007 )
产品货号. M14006 CAS No. 313368-91-1
Lumateperone (ITI-007) is a potent 5-HT2A antagonist (Ki=0.54 nM), postsynaptic D2 antagonist(Ki=32 nM), and SERT blocker (Ki= 61 nM).
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥3540 | 有现货 |
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10MG | ¥267 | 有现货 |
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25MG | ¥429 | 有现货 |
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50MG | ¥624 | 有现货 |
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100MG | ¥956 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Lumateperone
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Lumateperone (ITI-007) is a potent 5-HT2A antagonist (Ki=0.54 nM), postsynaptic D2 antagonist(Ki=32 nM), and SERT blocker (Ki= 61 nM).
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产品描述Lumateperone (ITI-007) is a potent 5-HT2A antagonist (Ki=0.54 nM), postsynaptic D2 antagonist(Ki=32 nM), and SERT blocker (Ki= 61 nM); also shows affinity for D1; orally bioavailable and exhibits good antipsychotic efficacy in vivo.Schizophrenia Phase 3 Clinical
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同义词ITI-007
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通路Endocrinology/Hormones
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靶点5-HT Receptor
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受体5-HT Receptor
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研究领域Neurological Disease
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适应症Schizophrenia
化学信息
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CAS Number313368-91-1
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分子量393.50
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分子式C24H28FN3O
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(C1=CC=C(F)C=C1)CCCN2CC[C@@](N3CCN(C)C4=C3C5=CC=C4)([H])[C@@]5([H])C2
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化学全称1-(4-fluorophenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)butan-1-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Li P, et al. J Med Chem. 2014 Mar 27;57(6):2670-82.
2. Snyder GL, et al. Psychopharmacology (Berl). 2015 Feb;232(3):605-21.
2. Snyder GL, et al. Psychopharmacology (Berl). 2015 Feb;232(3):605-21.
产品手册
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