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Linopirdine
CAS No. 105431-72-9
Linopirdine ( DUP-996;Linopirine )
产品货号. M10251 CAS No. 105431-72-9
Linopirdine (DUP-996;Linopirine) is a potent Kv7 (KCNQ) voltage-gated potassium channels blcoker; blocks KV7.1+7.3 (KCNQ2+3)/M-currents (IC50=4-7 uM) and KV7.1 (KCNQ1) homomeric channels (IC50=8.9 uM).
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥413 | 有现货 |
|
| 5MG | ￥648 | 有现货 |
|
| 10MG | ￥1037 | 有现货 |
|
| 25MG | ￥1936 | 有现货 |
|
| 50MG | ￥3345 | 有现货 |
|
| 100MG | ￥4779 | 有现货 |
|
| 200MG | ￥6909 | 有现货 |
|
| 500MG | ￥10287 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Linopirdine
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Linopirdine (DUP-996;Linopirine) is a potent Kv7 (KCNQ) voltage-gated potassium channels blcoker; blocks KV7.1+7.3 (KCNQ2+3)/M-currents (IC50=4-7 uM) and KV7.1 (KCNQ1) homomeric channels (IC50=8.9 uM).
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产品描述Linopirdine (DUP-996;Linopirine) is a potent Kv7 (KCNQ) voltage-gated potassium channels blcoker; blocks KV7.1+7.3 (KCNQ2+3)/M-currents (IC50=4-7 uM) and KV7.1 (KCNQ1) homomeric channels (IC50=8.9 uM); inhibits M-type K+ current, increases acetylcholine release in rat hippocampal CA1 neurons; active in vivo.Alzheimer Disease Phase 1 Discontinued
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同义词DUP-996;Linopirine
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通路Cell Cycle/DNA Damage
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靶点Potassium Channel
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受体Potassium Channel
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研究领域Neurological Disease
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适应症Alzheimer Disease
化学信息
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CAS Number105431-72-9
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分子量391.47
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分子式C26H21N3O
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C1N(C2=CC=CC=C2)C3=C(C=CC=C3)C1(CC4=CC=NC=C4)CC5=CC=NC=C5
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化学全称1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Schnee ME, et al. J Pharmacol Exp Ther. 1998 Aug;286(2):709-17.
2. Wang HS, et al. Science. 1998 Dec 4;282(5395):1890-3.
3. Zaczek R, et al. J Pharmacol Exp Ther. 1998 May;285(2):724-30.
2. Wang HS, et al. Science. 1998 Dec 4;282(5395):1890-3.
3. Zaczek R, et al. J Pharmacol Exp Ther. 1998 May;285(2):724-30.
产品手册
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