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Linifanib
CAS No. 796967-16-3
Linifanib ( ABT-869;AL-39324;ABT 869;ABT869;AL 39324;AL39324 )
产品货号. M15985 CAS No. 796967-16-3
A potent multi-RTKs inhibitor of members of VEGFR and PDGFR families.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥348 | 有现货 |
|
| 10MG | ￥624 | 有现货 |
|
| 25MG | ￥1037 | 有现货 |
|
| 50MG | ￥1604 | 有现货 |
|
| 100MG | ￥2333 | 有现货 |
|
| 200MG | ￥4301 | 有现货 |
|
| 500MG | ￥6950 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Linifanib
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A potent multi-RTKs inhibitor of members of VEGFR and PDGFR families.
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产品描述A potent multi-RTKs inhibitor of members of VEGFR and PDGFR families with IC50 of 4/3/3/14/4/66/190/170 nM for KDR/FLT1/CSF1R/KIT/FLT3/PDGFRβ/FLT4/Tie2, respectively; much less active (IC50>10 uM) against other nonrelated tyrosine kinases, such as steroid receptor coactivator and EGFR; inhibits RTK phosphorylation (IC50=2, 4, and 7 nM for PDGFRβ, KDR, and CSF-1R, respectively) and VEGF-stimulated proliferation (IC50=0.2 nM for human endothelial cells); exhibits efficacy in human fibrosarcoma and breast, colon, and small cell lung carcinoma xenograft models (ED50=1.5-5 mg/kg, twice daily).Colon Cancer Phase 2 Discontinued
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同义词ABT-869;AL-39324;ABT 869;ABT869;AL 39324;AL39324
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通路Angiogenesis
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靶点VEGFR
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受体CSF-1R;FLT3;Kit;VEGFR1/FLT1;VEGFR2/KDR
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研究领域Cancer
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适应症Colon Cancer
化学信息
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CAS Number796967-16-3
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分子量375.40
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分子式C21H18FN5O
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESO=C(N)N(C1=CC=C(C2=CC=CC3=C2C(N)=NN3)C=C1)C4=CC(C)=CC=C4F
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化学全称Urea, N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Dai Y, et al. J Med Chem. 2007 Apr 5;50(7):1584-97.
2. Shankar DB, et al. Blood. 2007 Apr 15;109(8):3400-8.
3. Albert DH, et al. Mol Cancer Ther. 2006 Apr;5(4):995-1006.
2. Shankar DB, et al. Blood. 2007 Apr 15;109(8):3400-8.
3. Albert DH, et al. Mol Cancer Ther. 2006 Apr;5(4):995-1006.
产品手册
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