Lindleyin ( —— )

产品货号. M22052 CAS No. 59282-56-3

COA

Datasheet

HNMR

HPLC

MSDS

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产品名称

Lindleyin
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Lindleyin is a novel phytoestrogen and might trigger many of the biological responses evoked by the physiological estrogens.
产品描述

Lindleyin is a novel phytoestrogen and might trigger many of the biological responses evoked by the physiological estrogens.One herbal extract, Rhei rhizoma (rhubarb), acts as an agonist to both ERalpha and ERbeta. The phytochemical Lindleyin, a major component of rhubarb, might contribute to this estrogenic activity through ERalpha and ERbeta. 4-Hydroxytamoxifen, an ER antagonist, completely reversed the estrogenic activity of Lindleyin. Lindleyin binds to ERalpha in vitro, as demonstrated using a fluorescent polarization assay. The in vivo effect of rhubarb extract was studied using a vitellogenin assay system in the freshwater fish, Japanese medaka (Oryzias latipes). There were marked increases in serum vitellogenin levels in male medaka exposed to rhubarb extract.
同义词

——
通路

Endocrinology/Hormones
靶点

Estrogen Receptor/ERR
受体

Estrogen Receptor/ERR;Estrogen/progestogen Receptor
研究领域

——
适应症

——

CAS Number

59282-56-3
分子量

478.45
分子式

C23H26O11
纯度

>98% (HPLC)
溶解度

——
SMILES

CC(=O)CCC1=CC=C(O[C@@H]2O[C@H](COC(=O)C3=CC(O)=C(O)C(O)=C3)[C@@H](O)[C@H](O)[C@H]2O)C=C1
化学全称

——

1.The phytochemical lindleyin, isolated from Rhei rhizoma, mediates hormonal effects through estrogen receptors.J Endocrinol. 2002 Nov;175(2):289-96.

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