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Lerisetron
CAS No. 143257-98-1
Lerisetron ( —— )
产品货号. M21941 CAS No. 143257-98-1
Lerisetron 是 3 型血清素 (5-HT3) 受体拮抗剂，具有止吐活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥794 | 有现货 |
|
| 5MG | ￥1239 | 有现货 |
|
| 10MG | ￥1879 | 有现货 |
|
| 25MG | ￥3329 | 有现货 |
|
| 50MG | ￥4836 | 有现货 |
|
| 100MG | ￥7031 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Lerisetron
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Lerisetron 是 3 型血清素 (5-HT3) 受体拮抗剂，具有止吐活性。
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产品描述Lerisetron is an antagonist of serotonin type 3 (5-HT3) receptor, with antiemetic activity.showed a decrease in total clearance and distribution volume of the central compartment in old rats. The lerisetron free (unbound) fraction remained unchanged among the groups, and there were no significant differences in alpha(1)-acid glycoprotein levels. The concentration-effect relationship was best described by a sigmoid E(max) model. Since the drug concentration in plasma at half-maximal effect (EC(50)) decreased in old rats, an increased sensitivity to the effect of lerisetron in old animals could be expected.
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体外实验——
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体内实验Lerisetron (50-200 μg/kg; IV; single) exhibits CL of 0.004-0.005 L/min, Vds of 0.88-0.96 L, MRT0-LAST of 224-337.1 min and AUC∞ of 57.7-66.1 μg·min/L in rats.Lerisetron (2-10 μg/kg; IV; single) causes rapid recovery from bradycardia.Pharmacokinetic Parameters of Lerisetron in Sprague-Dawley rats.
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同义词——
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通路Endocrinology/Hormones
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靶点5-HT Receptor
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受体5-HT3
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研究领域——
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适应症——
化学信息
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CAS Number143257-98-1
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分子量292.38
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分子式C18H20N4
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纯度>98% (HPLC)
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溶解度DMSO:53 mg/ml(181.27 mM)
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SMILESC(c1ccccc1)n1c(nc2ccccc12)N1CCNCC1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Nerea, Jauregizar, Antonio, et al. Age-Related Changes in Pharmacokinetics and Pharmacodynamics of Lerisetron in the Rat: A Population Pharmacokinetic Model[J]. Gerontology, 2003
2. Strenge H , Goebel S , Kowalski J , et al. Effects of Lerisetron, a New 5-HT3 Receptor Antagonist, on Ipecacuanha- induced Emesis in Healthy Volunteers[J]. Arzneimittelforschung, 2002, 52(09):689-694.
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