Lasmiditan ( COL-144; LY573144 )

产品货号. M18554 CAS No. 439239-90-4

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产品名称

Lasmiditan
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Lasmiditan, also known as COL-144 and LY573144, is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1=2.21 μM) without vasoconstrictor activity that seemed effective when given as an intravenous infusion in a proof-of-concept migraine study.
产品描述

Lasmiditan, also known as COL-144 and LY573144, is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1=2.21 μM) without vasoconstrictor activity that seemed effective when given as an intravenous infusion in a proof-of-concept migraine study. Lasmiditan showed efficacy in its primary endpoint, with a 2-hour placebo-subtracted headache response of 28.8%, though with frequent reports of dizziness, paresthesias, and vertigo.
同义词

COL-144; LY573144
通路

Others
靶点

Other Targets
受体

5-HT1F
研究领域

Neurological Disease
适应症

——

1. Nelson DL, et al. Cephalalgia. 2010 Oct;30(10):1159-69.

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