LUF6000

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

LUF6000 是人类 A3 腺苷受体的有效、选择性、正变构调节剂（增强剂）。

LUF6000 is a potent, selective, positive allosteric modulator (enhancer) of human A3 adenosine receptor, enhance Emax but without affecting agonist potency; enhance sagonist efficacy in a functional assay by 45% and decreases dissociation rate similarly without influencing agonist potency, LUF6000 is superior to that of DU124183.

Modulatory effect of 10 μM LUF6000 on Cl-IB-MECA-induced [35S]GTPγS binding in assays with HEK 293 cell membranes expressing human, dog, rabbit, or mouse A3 adenosine receptors with EC50 ranging from 39 to 172 nM.

LUF6000 induces anti-inflammatory effect in 3 experimental animal models of rat adjuvant induced arthritis, monoiodoacetate induced osteoarthritis, and concanavalin A induced liver inflammation in mice.

LUF-6000 | LUF 6000

Apoptosis

Adenosine Receptor

Adenosine Receptor

Cardiovascular Disease

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890087-21-5

411.327

C22H20Cl2N4

>98% (HPLC)

10 mM in DMSO

ClC1=CC=C(NC2=NC3=CC=CC=C3C4=C2NC(C5CCCCC5)=N4)C=C1Cl

3H-Imidazo[4,5-c]quinolin-4-amine, 2-cyclohexyl-N-(3,4-dichlorophenyl)-

(-20℃)

With Ice Pack

≥ 2 years