LSZ102 ( LSZ 102;LSZ-102 )

产品货号. M13402 CAS No. 2135600-76-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

LSZ102
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

LSZ102 is a potent, orally bioavailable, selective estrogen receptor degrader (SERD) with ERα transcription IC50 of 6 nM and ERα degradation IC50 of 0.2 nM.
产品描述

LSZ102 is a potent, orally bioavailable, selective estrogen receptor degrader (SERD) with ERα transcription IC50 of 6 nM and ERα degradation IC50 of 0.2 nM; robustly causes inhibition of cell proliferation in MCF-7 cells with IC50 of 1.7 nM, inhibits the mRNA level of canonical endogenous ER target gene GREB1 with IC50 of 8.9 nM; demonstrates anti-tumor efficacy in the ER+ human breast cancer MCF-7 xenograft model (10 mg/kg).Breast Cancer Phase 1 Clinical
同义词

LSZ 102;LSZ-102
通路

Endocrinology/Hormones
靶点

Estrogen Receptor/ERR
受体

Estrogen Receptor/ERR
研究领域

Cancer
适应症

Breast Cancer

CAS Number

2135600-76-7
分子量

470.46
分子式

C25H17F3O4S
纯度

>98% (HPLC)
溶解度

DMSO : 100 mg/mL 212.56 mM; H2O : < 0.1 mg/mL
SMILES

O=C(O)/C=C/C1=CC=C(OC2=C(C3=CC=C(F)C=C3C(F)(F)C)SC4=CC(O)=CC=C42)C=C1
化学全称

(E)-3-(4-((2-(2-(1,1-Difluoroethyl)-4-fluorophenyl)-6-hydroxybenzo[b]thiophen-3-yl)oxy)phenyl)acrylic acid

1. Tria GS, et al. J Med Chem. 2018 Apr 12;61(7):2837-2864.

计算器

产品手册

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