021-51111890
购物车（0）
sales@molnova.cn
LMD-009
CAS No. 950195-51-4
LMD-009 ( LMD 009 | LMD009 )
产品货号. M16794 CAS No. 950195-51-4
LMD-009 (LMD 009, LMD009) 是一种有效的、选择性的非肽 CCR8 激动剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 25MG | ￥7468 | 有现货 |
|
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称LMD-009
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述LMD-009 (LMD 009, LMD009) 是一种有效的、选择性的非肽 CCR8 激动剂。
-
产品描述LMD-009 (LMD 009, LMD009) is a potent, selective, nonpeptide CCR8 agonist that stimulates CCR8-mediated chemotaxis, inositol phosphate accumulation and calcium release with EC50 of 11-87 nM; displays no activity against other chemokine receptors.
-
体外实验Cell Viability Assay Cell Line:COS-7 cells Concentration:0-20 nM Incubation Time:90 min Result:Stimulated inositol phosphate accumulation in COS-7 cells expressing the human CCR8 receptor with an EC50 value of 11 nM. Inhibited none of the receptors of other human chemokine receptors.Cell Viability Assay Cell Line:Chinese hamster ovary cells Concentration:0-100 nM Incubation Time:1 hour Result:Regulated calcium release in Chinese hamster ovary cells with an EC50 value 87 nM.Cell Migration Assay Cell Line:Lymphocyte L1.2 cells.Concentration:0.1 nM- 100 μM Incubation Time:40 min Result:Exhibited an Ki value of 66 nM with L1.2 cells and specifically bound 125I-CCL1.
-
体内实验——
-
同义词LMD 009 | LMD009
-
通路GPCR/G Protein
-
靶点Chemokine Receptor
-
受体Chemokine Receptor
-
研究领域——
-
适应症——
化学信息
-
CAS Number950195-51-4
-
分子量471.601
-
分子式C29H33N3O3
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO : 250 mg/mL (530.12 mM)
-
SMILESO=C1NCN(CCC2=CC=CC=C2)C13CCN(CC4=CC=CC(OC5=CC=CC=C5OC)=C4)CC3
-
化学全称8-[3-(2-methoxyphenoxy)benzyl]-1-phenethyl-1,3,8-triaza-spiro[4.5]decan-4-one
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Jensen PC, et al. Mol Pharmacol. 2007 Aug;72(2):327-40.
