L-685,458
CAS No. 292632-98-5
L-685,458 ( L685458; L-685458; L 685458 )
产品货号. M18379 CAS No. 292632-98-5
L-685, 458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.
纯度: 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥3013 | 有现货 |
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10MG | ¥4682 | 有现货 |
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25MG | ¥7557 | 有现货 |
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50MG | ¥10287 | 有现货 |
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100MG | ¥13689 | 有现货 |
|
200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称L-685,458
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述L-685, 458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.
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产品描述L685458 is a potent and selective γ -secretase inhibitor (IC50 = 17 nM) that displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. L685458 also exhibits equal potency for inhibition of A β 40 and A β 42 peptides (IC50 values are 48 and 67 nM respectively in human neuroblastoma cells). Also regulates CXCR4 and VEGFR2 expression through inhibition of Notch signaling in vitro.
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同义词L685458; L-685458; L 685458
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通路Others
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靶点Other Targets
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受体γ secretase
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研究领域Neurological Disease
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适应症——
化学信息
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CAS Number292632-98-5
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分子量672.85
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分子式C39H52N4O6
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纯度98%
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溶解度DMSO : ≥ 31 mg/mL; 46.07 mM
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SMILESCC(C)C[C@H](NC(=O)[C@@H](C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
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化学全称tert-butyl ((2S,3R,5R)-6-(((S)-1-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-5-benzyl-3-hydroxy-6-oxo-1-phenylhexan-2-yl)carbamate.
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Shearman M S, Beher D, Clarke E E, et al. L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid β-protein precursor γ-secretase activity[J]. Biochemistry, 2000, 39(30): 8698-8704.
产品手册
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