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L-685,458

CAS No. 292632-98-5

L-685,458 ( L685458; L-685458; L 685458 )

产品货号. M18379 CAS No. 292632-98-5

L-685, 458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.

纯度: 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥3013 有现货
10MG ¥4682 有现货
25MG ¥7557 有现货
50MG ¥10287 有现货
100MG ¥13689 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    L-685,458
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    L-685, 458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.
  • 产品描述
    L685458 is a potent and selective γ -secretase inhibitor (IC50 = 17 nM) that displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. L685458 also exhibits equal potency for inhibition of A β 40 and A β 42 peptides (IC50 values are 48 and 67 nM respectively in human neuroblastoma cells). Also regulates CXCR4 and VEGFR2 expression through inhibition of Notch signaling in vitro.
  • 同义词
    L685458; L-685458; L 685458
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    γ secretase
  • 研究领域
    Neurological Disease
  • 适应症
    ——

化学信息

  • CAS Number
    292632-98-5
  • 分子量
    672.85
  • 分子式
    C39H52N4O6
  • 纯度
    98%
  • 溶解度
    DMSO : ≥ 31 mg/mL; 46.07 mM
  • SMILES
    CC(C)C[C@H](NC(=O)[C@@H](C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
  • 化学全称
    tert-butyl ((2S,3R,5R)-6-(((S)-1-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-5-benzyl-3-hydroxy-6-oxo-1-phenylhexan-2-yl)carbamate.

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Shearman M S, Beher D, Clarke E E, et al. L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid β-protein precursor γ-secretase activity[J]. Biochemistry, 2000, 39(30): 8698-8704.
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