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L-002
CAS No. 321695-57-2
L-002 ( NSC 764414 | L002 )
产品货号. M14048 CAS No. 321695-57-2
L-002 (NSC 764414, L002) 是一种新型强效、特异性乙酰转移酶 p300 (KAT3B) 抑制剂，IC50 为 1.98 uM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥275 | 有现货 |
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| 5MG | ￥437 | 有现货 |
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| 10MG | ￥656 | 有现货 |
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| 25MG | ￥1450 | 有现货 |
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| 50MG | ￥2778 | 有现货 |
|
| 100MG | ￥4593 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称L-002
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述L-002 (NSC 764414, L002) 是一种新型强效、特异性乙酰转移酶 p300 (KAT3B) 抑制剂，IC50 为 1.98 uM。
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产品描述L-002 (NSC 764414, L002) is a novel potent, specific acetyltransferase p300 (KAT3B) inhibitor with IC50 of 1.98 uM; also shows weak inhibitory activity against PCAF (KAT2B) and GCN5 (KAT2A) with IC50 of 34.7 and 33.9 uM, displays no inhibition against Tip60, MYST2 and MYST4 (IC50>100 uM), as well as a panel of HDACs and HMTs; inhibits acetylation of histones and p53, and suppresses STAT3 activation in cell-based assays; exhibits extreme sensitivity against leukemia, breas and lymphoma cell lines; potently suppresses tumor growth and histone acetylation of MDA-MB-468 xenografts.
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体外实验——
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体内实验Animal Model:Wild‐type C57BL/6 male mice planted with osmotic minipumps ( Angiotensin II 1500?ng/kg/min) for 4 weeks Dosage:20?μg/gm body weight; every 3rd day; 2 weeks Administration:Intraperitoneal injection Result:Reversed hypertension-induced cardiac fibrosis in mice.
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同义词NSC 764414 | L002
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通路Chromatin/Epigenetic
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靶点HAT
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受体HAT
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研究领域——
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适应症——
化学信息
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CAS Number321695-57-2
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分子量321.35
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分子式C15H15NO5S
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 100 mg/mL (311.19 mM)
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SMILESCC1=CC(=NOS(=O)(=O)C2=CC=C(C=C2)OC)C=C(C1=O)C
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化学全称2,6-dimethyl-2,5-cyclohexadiene-1,4-dione 4-[O-[(4-methoxyphenyl)sulfonyl]oxime]
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Rai R, et al. Epigenetics. 2017;12(11):1004-1013.
2. Yang H, et al. Mol Cancer Ther. 2013 May;12(5):610-20.
