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KYA-1797K
CAS No. 1956356-56-1
KYA-1797K ( KYA 1797K )
产品货号. M13063 CAS No. 1956356-56-1
KY1220 的衍生物，具有改善的 Wnt/β-catenin 信号传导抑制活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥332 | 有现货 |
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| 5MG | ￥543 | 有现货 |
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| 10MG | ￥948 | 有现货 |
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| 25MG | ￥2082 | 有现货 |
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| 50MG | ￥3540 | 有现货 |
|
| 100MG | ￥5249 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称KYA-1797K
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述KY1220 的衍生物，具有改善的 Wnt/β-catenin 信号传导抑制活性。
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产品描述A derivative of KY1220 with improved inhibitory activity for Wnt/β-catenin signaling; dose-dependently decreases Wnt3a-CM-induced TOPflash reporter activation with IC50 of 0.75 uM; more effectively reduces the levels of both β-catenin and pan-Ras as well as the activities of ERK and Akt in SW480 cells; binds to Axin (Kd to WT axin-RGS=0.29 uM) and destabilizes b-catenin and Ras; inhibits growth of CRC cells with GI50 of 4-5 uM; suppresses the tumors induced by APC and KRAS mutations in tumor xenograft mice (25 mg/kg, i.p.).
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体外实验——
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体内实验——
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同义词KYA 1797K
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通路Wnt/Notch/Hedgehog
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靶点Beta-catenin
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受体Wnt/β-catenin
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研究领域Cancer
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适应症——
化学信息
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CAS Number1956356-56-1
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分子量442.501
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分子式C17H11KN2O6S2
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纯度>98% (HPLC)
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溶解度Ethanol: <1 mg/mL; DMSO: 20 mg/mL (45.2 mM); Water: 20 mg/mL (45.2 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESO=C([O-])CCN(C/1=O)C(SC1=C/C2=CC=C(C3=CC=C([N+]([O-])=O)C=C3)O2)=S.[K+]
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化学全称potassium (Z)-3-(5-((5-(4-nitrophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)propanoate
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Cha PH, et al. Nat Chem Biol. 2016 Aug;12(8):593-600.
2. Cha PH, et al. BMB Rep. 2016 Sep;49(9):455-6.
