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E-7386
CAS No. 1799824-08-0
E-7386 ( E7386 )
产品货号. M12730 CAS No. 1799824-08-0
E-7386 (E7386) 是一种有效的、口服活性的 CBP/β-catenin 调节剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2179 | 有现货 |
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| 10MG | ￥3313 | 有现货 |
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| 25MG | ￥5524 | 有现货 |
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| 50MG | ￥7849 | 有现货 |
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| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称E-7386
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述E-7386 (E7386) 是一种有效的、口服活性的 CBP/β-catenin 调节剂。
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产品描述E-7386 (E7386) is a potent, orally active modulator of CBP/beta-catenin, disrupts the interaction and inhibits canonical Wnt signaling pathway /TCF reporter gene activity in LiCl-stimulated HEK-293 and MDA-MB-231 with IC50 of 55 and 73 nM, respectively; exhibits anti-tumor activity in vitro tumor proliferation panel against 28 human tumor cell lines; modulates the expression of Wnt signaling pathway related genes including AXIN2 and other genes, significantly suppressed the number of polyposis in a dose dependent manner at the dose 8.5-50 mg/kg, also significantly changed the expressions of Wnt related genes in whisker follicle of ApcMin/+mice model.
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体外实验——
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体内实验E-7386 is an orally active CBP/beta-catenin modulator which can induce T cells infiltration into tumor and enhance antitumor activity of anti-PD-1 mAb in Wnt1 tumor syngeneic mice model. E-7386 shows significant antitumor activity in Wnt1 model.Infiltration of T cells is limited in vehicle control group, but T cell infiltration into tumors is clearly observed in E-7386 treatment group.
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同义词E7386
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通路Wnt/Notch/Hedgehog
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靶点Beta-catenin
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受体Beta-catenin
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研究领域——
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适应症——
化学信息
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CAS Number1799824-08-0
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分子量725.87
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分子式C39H48FN9O4
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 125 mg/mL (172.21 mM)
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SMILESCCN1CCN(CC1)C2CN(C2)C3=CC=CC(=N3)CN4CC5N(C(C4=O)CC6=C(C=C(C=C6)O)F)C(=O)CN(N5C(=O)NCC7=CC=CC=C7)CC=C
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化学全称(6S,9aS)-2-allyl-N-benzyl-8-((6-(3-(4-ethylpiperazin-1-yl)azetidin-1-yl)pyridin-2-yl)methyl)-6-(2-fluoro-4-hydroxybenzyl)-4,7-dioxohexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Kazuhiko Yamada, et al. Abstract 5177: E7386 : First-in-class orally active CBP/beta-catenin modulator as an anticancer agent. AACR 2017.
