KRCA-0008
CAS No. 1472795-20-2
KRCA-0008 ( KRCA 0008;KRCA0008 )
产品货号. M12023 CAS No. 1472795-20-2
KRCA-0008 is a potent, selective ALK inhibitor with IC50 of 12 nM (wt ALK).
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥316 | 有现货 |
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10MG | ¥551 | 有现货 |
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25MG | ¥1045 | 有现货 |
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50MG | ¥2066 | 有现货 |
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100MG | ¥3491 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称KRCA-0008
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述KRCA-0008 is a potent, selective ALK inhibitor with IC50 of 12 nM (wt ALK).
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产品描述KRCA-0008 is a potent, selective ALK inhibitor with IC50 of 12 nM (wt ALK), also is potent against various ALK mutants, including L1196M, F1174L, R1275Q, and C1156Y (IC50=5-75 nM); weakly inhibits IR (IC50=210 nM), inhibits H3122 and BaF3 EML4-ALK L1196M cell proliferation with IC50 of 80 and 68 nM, respectively; demonstrates in vivo efficacy comparable to Crizotinib in xenograft mice model, has drug-like properties without hERG concerns.
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同义词KRCA 0008;KRCA0008
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通路Angiogenesis
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靶点ALK
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受体ACK;ALK
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研究领域Cancer
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适应症——
化学信息
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CAS Number1472795-20-2
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分子量609.12
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分子式C30H37ClN8O4
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESClC1=CN=C(NC2=CC=C(N3CCN(C(C)=O)CC3)C=C2OC)N=C1NC4=CC=C(N5CCN(C(C)=O)CC5)C=C4OC
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化学全称Ethanone, 1,1'-[(5-chloro-2,4-pyrimidinediyl)bis[imino(3-methoxy-4,1-phenylene)-4,1-piperazinediyl]]bis-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Park CH, et al. Bioorg Med Chem Lett. 2013 Nov 15;23(22):6192-6.
2. Kang CH, et al. Biochem Biophys Res Commun. 2015 Aug 28;464(3):762-7.
3. Lee HJ, et al. Arch Pharm Res. 2014;37(9):1130-8.
2. Kang CH, et al. Biochem Biophys Res Commun. 2015 Aug 28;464(3):762-7.
3. Lee HJ, et al. Arch Pharm Res. 2014;37(9):1130-8.
产品手册
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