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KPT-330
CAS No. 1421923-86-5
KPT-330 ( (E)-RN )
产品货号. M11769 CAS No. 1421923-86-5
KPT-330 在 11 种 NSCLC 细胞系中抑制增殖并诱导细胞周期停滞和凋亡相关蛋白。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥389 | 有现货 |
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| 5MG | ￥583 | 有现货 |
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| 10MG | ￥753 | 有现货 |
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| 25MG | ￥1604 | 有现货 |
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| 50MG | ￥2892 | 有现货 |
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| 100MG | ￥4285 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称KPT-330
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述KPT-330 在 11 种 NSCLC 细胞系中抑制增殖并诱导细胞周期停滞和凋亡相关蛋白。
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产品描述KPT-330 inhibited proliferation and induced cell cycle arrest and apoptosis-related proteins in 11 NSCLC cells lines. Moreover, the combination of KPT-330 with cisplatin synergistically enhanced the cell kill of the NSCLC cells in vitro. Human NSCLC tumours growing in immunodeficient mice were markedly inhibited by KPT-330. Also, KPT-330 was effective even against NSCLC cells with a transforming mutation of either exon 20 of EGFR, TP53, phosphatase and tensin homologue, RAS or PIK3CA, suggesting the drug might be effective against a variety of lung Ys irrespective of their driver mutation.
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体外实验——
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体内实验——
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同义词(E)-RN
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通路Membrane Transporter/Ion Channel
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靶点CRM1
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受体CRM1| XPO1
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研究领域——
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适应症——
化学信息
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CAS Number1421923-86-5
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分子量443.31
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分子式C17H11F6N7O
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纯度>98% (HPLC)
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溶解度Soluble in DMSO
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SMILESC1=CN=C(C=N1)NNC(=O)/C=C/N2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Christopher J. Walker,et al. Blood. 2013 Oct 24; 122(17): 3034–3044.
