KLH45

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

KLH45 是有效、选择性的 DDHD2 抑制剂，其 IC50 值为 1.3 nM。

KLH45 is a potent and selective DDHD2 inhibitor, with an IC50 of 1.3 nM.

KLH45 (25 nM, 4 h) completely inactivats DDHD2 (>95% inhibition) in Neuro2A cells and shows no cross-reactivity with any of the other 40+ detected serine hydrolases with the exception of ABHD6.KLH45 (2 μM) increases LD formation in fatty acid-supplemented DDHD2-expressing cells.Cell Viability Assay Cell Line:COS-7 cells.Concentration:2 μM.Incubation Time:16 h.Result:Selectively blocked DDHD2 activity.

KLH45 (20 mg/kg; administered every 12 h) for a total of 4 d exhibits significant elevations in several of the TAGs that accumulated in the brains of DDHD2?/? mice.Animal Model:Mice.Dosage:5-40 mg/kg.Administration:IP, once.Result:Did not show altered brain TAGs.

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Metabolic Enzyme/Protease

Phosphatase

Phosphatase

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1632236-44-2

458.48

C24H25F3N4O2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (218.11 mM; 超声助溶 )

FC(F)(F)Oc1ccc(cc1)-c1cnn(n1)C(=O)N(CCc1ccccc1)C1CCCCC1

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(-20℃)

With Ice Pack

≥ 2 years