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KIN-1408
CAS No. 1903800-11-2
KIN-1408 ( KIN-1408 | KIN 1408 )
产品货号. M12985 CAS No. 1903800-11-2
一种小分子 MAVS 依赖性 IRF3 激动剂，对黄病毒科具有抗病毒活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 10MG | ￥5292 | 有现货 |
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| 50MG | ￥15876 | 有现货 |
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| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称KIN-1408
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述一种小分子 MAVS 依赖性 IRF3 激动剂，对黄病毒科具有抗病毒活性。
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产品描述A small-molecule MAVS-dependent IRF3 agonist that shows antiviral activity against Flaviviridae, Filoviridae (Ebola virus), Orthomyxoviridae (influenza A virus), Arenaviridae (Lassa virus) and Paramyxoviridae (RSVs, Nipah virus); induces relocalization of pTBK1 from centrosomes to mitochondria, and increases CASP3-mediated cell death; the RIG-I-like receptor (RLR) agonist.
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体外实验KIN1408 has the potency to drive IRF3 activation to induce innate immune gene (MDA5, RIG-1, Mx1, IRF7, and IFIT1 in THP-1 cells) expression and that concomitantly suppress dengue virus2 RNA to levels. KIN1408 also exhibits activity against HCV, influenza A, Ebola, Nipah, and Lassa viruses.
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体内实验——
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同义词KIN-1408 | KIN 1408
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通路Immunology/Inflammation
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靶点RLR
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受体RLR
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研究领域Infection
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适应症——
化学信息
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CAS Number1903800-11-2
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分子量479.4985
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分子式C25H19F2N3O3S
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 39 mg/mL
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SMILESOC1=C2N=CC=CC2=CC=C1C(C3=CC=C(OC(F)F)C=C3)NC4=NC5=CC(OC)=CC=C5S4
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化学全称7-((4-(difluoromethoxy)phenyl)((5-methoxybenzo[d]thiazol-2-yl)amino)methyl)quinolin-8-ol
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Green RR, et al. Genom Data. 2016 Feb 1;7:290-2.
2. Pattabhi S, et al. J Virol. 2015 Dec 16;90(5):2372-87.
3. Onorati M, et al. Cell Rep. 2016 Sep 6;16(10):2576-92.
