KH7 ( KH-7;KH 7;sAC inhibitor KH7 )

产品货号. M14099 CAS No. 330676-02-3

COA

Datasheet

HNMR

HPLC

MSDS

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产品名称

KH7
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A potent, specific soluble adenylyl cyclase (sAC) inhibitor that inhibits Mn2+-dependent sAC with IC50 of 2.7 uM.
产品描述

A potent, specific soluble adenylyl cyclase (sAC) inhibitor that inhibits Mn2+-dependent sAC with IC50 of 2.7 uM; inhibits physiologically stimulated sAC with similar potency with IC50 of 8.0 uM, completely blocks the capacitation-induced rise in cAMP in wild-type sperm at 10 uM, inhibits in vitro fertilization.
同义词

KH-7;KH 7;sAC inhibitor KH7
通路

Metabolic Enzyme/Protease
靶点

Adenylate Cyclase
受体

Adenylate Cyclase
研究领域

——
适应症

——

CAS Number

330676-02-3
分子量

419.30
分子式

C17H15BrN4O2S
纯度

>98% (HPLC)
溶解度

DMSO : ≥ 100 mg/mL 238.49 mM; H2O : < 0.1 mg/mL
SMILES

CC(SC1=NC2=CC=CC=C2N1)C(N/N=C/C3=CC(Br)=CC=C3O)=O
化学全称

(E)-2-((1H-benzo[d]imidazol-2-yl)thio)-N'-(5-bromo-2-hydroxybenzylidene)propanehydrazide

1. Bitterman JL, et al. J Pharmacol Exp Ther. 2013 Dec;347(3):589-98.
2. Hess KC, et al. Dev Cell. 2005 Aug;9(2):249-59.

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