
JZL195
CAS No. 1210004-12-8
JZL195 ( JZL195 | JZL-195 | JZL 195 )
产品货号. M17194 CAS No. 1210004-12-8
JZL195 是一种选择性有效的 FAAH/MAGL 双重抑制剂。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥316 | 有现货 |
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10MG | ¥527 | 有现货 |
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25MG | ¥1126 | 有现货 |
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50MG | ¥2130 | 有现货 |
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100MG | ¥3208 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称JZL195
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述JZL195 是一种选择性有效的 FAAH/MAGL 双重抑制剂。
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产品描述JZL195 is a potent and selective dual inhibitor of FAAH and monacylglycerol lipase (MAGL). JZL195 has greater anti-allodynic efficacy than selective FAAH, or MAGL inhibitors, plus a greater therapeutic window than a cannabinoid receptor agonist. JZL195 may have greater potential in alleviating neuropathic pain, compared to selective FAAH and MAGL inhibitors, or cannabinoid receptor agonists.
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体外实验JZL195 produces near-complete blockade of FP-Rh labeling of both mouse brain FAAH and MAGL at concentrations as low as 100 nM (IC50 values of 13 and 19 nM, respectively).JZL195 inhibits rat and human FAAH and MAGL enzymes with IC50 values in the range of ≈10-100 nM based on competitive ABPP assays.
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体内实验JZL195 (20 mg/kg; i.p.) produces an antinociceptive response in the tail immersion assay. Animal Model:Male C57BL/6J miceDosage:20 mg/kg Administration:Intraperitoneal injection Result:Produced a much greater antinociceptive response in the tail immersion assay compared with inhibitors of either FAAH or MAGL alone.
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同义词JZL195 | JZL-195 | JZL 195
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通路Others
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靶点Other Targets
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受体FAAH| MAGL
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研究领域Inflammation/Immunology
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适应症——
化学信息
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CAS Number1210004-12-8
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分子量433.46
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分子式C24H23N3O5
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纯度>98% (HPLC)
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溶解度DMSO : ≥ 42 mg/mL. 96.89 mM
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SMILES[O-][N+](=O)c1ccc(OC(=O)N2CCN(Cc3cc(Oc4ccccc4)ccc3)CC2)cc1
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化学全称4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Long JZ, et al. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20270-5.
产品手册




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