JZL195 ( JZL195 | JZL-195 | JZL 195 )

产品货号. M17194 CAS No. 1210004-12-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

JZL195
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

JZL195 是一种选择性有效的 FAAH/MAGL 双重抑制剂。
产品描述

JZL195 is a potent and selective dual inhibitor of FAAH and monacylglycerol lipase (MAGL). JZL195 has greater anti-allodynic efficacy than selective FAAH, or MAGL inhibitors, plus a greater therapeutic window than a cannabinoid receptor agonist. JZL195 may have greater potential in alleviating neuropathic pain, compared to selective FAAH and MAGL inhibitors, or cannabinoid receptor agonists.
体外实验

JZL195 produces near-complete blockade of FP-Rh labeling of both mouse brain FAAH and MAGL at concentrations as low as 100 nM (IC50 values of 13 and 19 nM, respectively).JZL195 inhibits rat and human FAAH and MAGL enzymes with IC50 values in the range of ≈10-100 nM based on competitive ABPP assays.
体内实验

JZL195 (20 mg/kg; i.p.) produces an antinociceptive response in the tail immersion assay. Animal Model:Male C57BL/6J miceDosage:20 mg/kg Administration:Intraperitoneal injection Result:Produced a much greater antinociceptive response in the tail immersion assay compared with inhibitors of either FAAH or MAGL alone.
同义词

JZL195 | JZL-195 | JZL 195
通路

Others
靶点

Other Targets
受体

FAAH| MAGL
研究领域

Inflammation/Immunology
适应症

——

1. Long JZ, et al. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20270-5.

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