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JPH203
CAS No. 1037592-40-7
JPH203 ( KYT-0353;KYT0353;KYT 0353;JPH-203 )
产品货号. M10188 CAS No. 1037592-40-7
JPH203 (KYT-0353)is a potent, selective L-type amino acid transporter 1 (LAT1, SLC7A5) inhibitor with IC50 of 60 nM (leucine uptake inhibition).
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥478 | 有现货 |
|
| 5MG | ￥680 | 有现货 |
|
| 10MG | ￥980 | 有现货 |
|
| 25MG | ￥1636 | 有现货 |
|
| 50MG | ￥2940 | 有现货 |
|
| 100MG | ￥3783 | 有现货 |
|
| 200MG | ￥5581 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称JPH203
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述JPH203 (KYT-0353)is a potent, selective L-type amino acid transporter 1 (LAT1, SLC7A5) inhibitor with IC50 of 60 nM (leucine uptake inhibition).
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产品描述JPH203 (KYT-0353)is a potent, selective L-type amino acid transporter 1 (LAT1, SLC7A5) inhibitor with IC50 of 60 nM (leucine uptake inhibition), but not LAT2; inhibits cell growth in HT-29 cells with IC50 of 4.1 uM, also inhibits (14)C-leucine uptake in mouse renal proximal tubule cells expressing LAT1 and inhibits cell growth with IC50 of 0.14 and 16.4 uM, respectively; significant inhibits HT-29 tumor growth in vivo.Solid Tumors Phase 1 Clinical
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同义词KYT-0353;KYT0353;KYT 0353;JPH-203
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通路Apoptosis
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靶点Apoptosis
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受体Apoptosis
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研究领域Cancer
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适应症Solid Tumors
化学信息
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CAS Number1037592-40-7
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分子量472.32
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分子式C23H19Cl2N3O4
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESC1=CC=C(C=C1)C2=NC3=CC(=CC(=C3O2)COC4=C(C=C(C=C4Cl)CC(C(=O)O)N)Cl)N
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化学全称L-Tyrosine, O-[(5-amino-2-phenyl-7-benzoxazolyl)methyl]-3,5-dichloro-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Oda K, et al. Cancer Sci. 2010 Jan;101(1):173-9.
2. Yun DW, et al. J Pharmacol Sci. 2014;124(2):208-17.
3. Wempe MF, et al. Drug Metab Pharmacokinet. 2012;27(1):155-61.
4. Rosilio C, et al. Leukemia. 2015 Jun;29(6):1253-66.
2. Yun DW, et al. J Pharmacol Sci. 2014;124(2):208-17.
3. Wempe MF, et al. Drug Metab Pharmacokinet. 2012;27(1):155-61.
4. Rosilio C, et al. Leukemia. 2015 Jun;29(6):1253-66.
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