• 咨询热线
    客服服务热线 13671568941/15317326293
  • 在线咨询
  • 微信客服
    微信客服
  • 公众号
    扫码关注公众号

Isosteviol

CAS No. 27975-19-5

Isosteviol ( (-)-Isosteviol | iso-Steviol )

产品货号. M18354 CAS No. 27975-19-5

异甜菊醇是一种常见的天然甜味剂,属于四环二萜苷类。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
50MG ¥316 有现货
100MG ¥551 有现货
500MG ¥1337 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Isosteviol
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    异甜菊醇是一种常见的天然甜味剂,属于四环二萜苷类。
  • 产品描述
    Isosteviol, a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside and its hydrolysis products, steviol, isosteviol and steviolbioside, have many biological activities, such as reducing blood glucose, lowering blood pressure, anti-inflammation, anti-tumor, anti-diarrhea, antibacterium, immunoregulation, etc.(In Vitro):Isosteviol ((-)-Isosteviol) dose-dependently relaxed the vasopressin (10-8 M)-induced vasoconstriction in isolated aortic rings with or without endothelium. However, in the presence of potassium chloride (3×10-2 M), the vasodilator effect of isosteviol on arterial strips disappeared. Only the inhibitors specific for the ATP-sensitive potassium (KATP) channel or small conductance calcium-activated potassium (SKCa) channel inhibited the vasodilator effect of isosteviol in isolated aortic rings contracted with 10-8 M vasopressin.The attenuation by isosteviol of the vasopressin- and phenylephrine-induced increase in [Ca2+]i was inhibited by glibenclamide, apamin and 4-aminopyridine but not by charybdotoxin. Furthermore, the inhibitory action of isosteviol on [Ca 2+]i was blocked when A7r5 cells co-treated with glibenclamide and apamin in conjunction with 4-aminopyridine were present.Isosteviol (1-100 micromol/l) inhibits angiotensin-II-induced DNA synthesis and endothelin-1 secretion. Measurements of 2'7'-dichlorofluorescin diacetate, a redox-sensitive fluorescent dye, showed an isosteviol-mediated inhibition of intracellular reactive oxygen species generated by the effects of angiotensin II.
  • 体外实验
    Isosteviol ((-)-Isosteviol) dose-dependently relaxed the vasopressin (10-8 M)-induced vasoconstriction in isolated aortic rings with or without endothelium. However, in the presence of potassium chloride (3×10-2 M), the vasodilator effect of isosteviol on arterial strips disappeared. Only the inhibitors specific for the ATP-sensitive potassium (KATP) channel or small conductance calcium-activated potassium (SKCa) channel inhibited the vasodilator effect of isosteviol in isolated aortic rings contracted with 10-8 M vasopressin. The attenuation by isosteviol of the vasopressin- and phenylephrine-induced increase in [Ca2+]i was inhibited by glibenclamide, apamin and 4-aminopyridine but not by charybdotoxin. Furthermore, the inhibitory action of isosteviol on [Ca 2+]i was blocked when A7r5 cells co-treated with glibenclamide and apamin in conjunction with 4-aminopyridine were present. Isosteviol (1-100 micromol/l) inhibits angiotensin-II-induced DNA synthesis and endothelin-1 secretion. Measurements of 2'7'-dichlorofluorescin diacetate, a redox-sensitive fluorescent dye, showed an isosteviol-mediated inhibition of intracellular reactive oxygen species generated by the effects of angiotensin II.
  • 体内实验
    ——
  • 同义词
    (-)-Isosteviol | iso-Steviol
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    COX-2| IL-6| NF-κB| Potassium Channel| TNF-α
  • 研究领域
    Others-Field
  • 适应症
    ——

化学信息

  • CAS Number
    27975-19-5
  • 分子量
    318.45
  • 分子式
    C20H30O3
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO : ≥ 100 mg/mL; 314.02 mM
  • SMILES
    C[C@]12CCC3[C@@]4(CCC[C@@]([C@H]4CC[C@@]3(C1)CC2=O)(C)C(=O)O)C
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Wang Z, et al. Biochem Biophys Res Commun,2012, 417(4): 1280-1285.
产品手册
关联产品
  • Egg Laying Hormone, ...

    Egg-laying hormone (ELH) is a neuropeptide synthesized by the bag cell neurons, Egg-laying hormone (ELH) induces egg laying and its correlated behavior in Aplysia californica. Egg-laying hormone (ELH) has been purified to homogeneity and Egg-laying hormone (ELH)'s primary structure has been determined. Egg-laying hormone (ELH) have 36 amino acid residues with a Mr of 4385 and a calculated isoelectric point of 9.7. Egg Laying Hormone of Aplysia induces a voltage-dependent slow inward current carried by Na+ in an identified motoneuron.

  • β-Eudesmol

    β-Eudesmol 是一种天然产物。

  • UK-5099

    UK 5099 是一种特异性、有效的 MPC 载体活性抑制剂。它有效抑制大鼠心脏线粒体的丙酮酸依赖性耗氧量(IC50:50 nM)。