Inosine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种嘌呤核苷，其次黄嘌呤通过 N9 氮与核糖的 C1 碳相连。

A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules.(In Vitro):Inosine dose-dependently stimulates cAMP production mediated through the A2AR.Inosine dose-dependently induces hA2AR-mediated ERK1/2 phosphorylation.Inosine (100 μM; 24 hours) reduces oxidative stress in MES 23.5 cells cultured with astrocytes.

Inosine dose-dependently stimulates cAMP production mediated through the A2AR.Inosine dose-dependently induces hA2AR-mediated ERK1/2 phosphorylation.Inosine (100 μM; 24 hours) reduces oxidative stress in MES 23.5 cells cultured with astrocytes.

Animal Model:Male/female C57BL/6 mice Dosage:1 mg/kg, 10 mg/kg, 100 mg/kg Administration:Intraperitoneal injection, 20 min before formalin treatment Result:Reduced flinching behaviour induced by formalin (2 %; 20 μL; intraplantar injection).

Inosine | NSC 20262 | NSC-20262 | NSC20262

Immunology/Inflammation

ROS

XO

——

——

58-63-9

268.23

C10H12N4O5

>98% (HPLC)

Water: 47 mg/mL warmed (175.22 mM); DMSO: 53 mg/mL warmed (197.59 mM)

OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C(N=CN=C32)O)O1)O)O

Inosine

(-20℃)

With Ice Pack

≥ 2 years