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IXA4

CAS No. 1185329-96-7

IXA4 ( —— )

产品货号. M28621 CAS No. 1185329-96-7

IXA4 是 IRE1/XBP1 的高选择性、无毒激活剂,通过激活 IRE1 减少 APP 分泌。 IXA4 刺激的 IRE1 激活也增强了胰腺功能。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥648 有现货
10MG ¥1037 有现货
25MG ¥1361 有现货
50MG ¥2195 有现货
100MG ¥3524 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    IXA4
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    IXA4 是 IRE1/XBP1 的高选择性、无毒激活剂,通过激活 IRE1 减少 APP 分泌。 IXA4 刺激的 IRE1 激活也增强了胰腺功能。
  • 产品描述
    IXA4 is a highly selective, nontoxic activator of IRE1/XBP1s and reduces APP secretion by activating IRE1. IXA4-stimulated IRE1 activation also enhanced pancreatic function.(In Vitro):In other cell lines including Huh7 and SHSY5Y cells, IXA4 selectively upregulated XBP1s mRNA relative to genes regulated by ATF6 (eg BiP) or PERK (eg CHOP). IXA4 reduces Aβ levels by 50% in conditioned medium prepared on CHO7PA2 cells expressing the V717F APP (APPV717F) mutant . IXA4 rescues mitochondrial defects in SH-SY5Y cells expressing disease-associated APP mutants. After 4 h of treatment in HEK293T cells, IXA4 promotes adaptive IRE1/XBP1s signaling, but not RIDD . IXA4 also promotes selective transcriptional remodeling of the ER proteostasis pathway relative to the cytoplasmic or mitochondrial pathway.
  • 体外实验
    IXA4 (10 μM; 4 hours) selectively upregulates XBP1s mRNA, relative to genes regulated by ATF6 (e.g., BiP) or PERK (e.g., CHOP), in other cell lines including Huh7 and SHSY5Y cells. IXA4 (10μM; 18 hours) reduces Aβ levels 50% in conditioned media prepared on CHO7PA2 cells expressing the V717F APP (APPV717F) mutant. IXA4 rescues mitochondrial defects in SH-SY5Y cells expressing disease-relevant APP mutants. IXA4 (10μM; 4 hours) promotes adaptive IRE1/XBP1s signaling, but not RIDD, following 4 hrs of treatment in HEK293T cells.IXA4 also promotes selective transcriptional remodeling of ER proteostasis pathways, relative to cytosolic or mitochondrial pathways.
  • 体内实验
    ——
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Calcium channel
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    1185329-96-7
  • 分子量
    436.5
  • 分子式
    C24H28N4O4
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?DMSO : 100 mg/mL (229.10 mM)
  • SMILES
    Cc(cc1)ccc1OCCN(C)C(Cn1ncc(NC(CCOc2ccccc2)=O)c1)=O
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.TakashiYamamoto, et al. Discovery, structure-activity relationship study, and oral analgesic efficacy of cyproheptadine derivatives possessing N-type calcium channel inhibitory activity. Bioorg Med Chem. 2006 Aug 1;14(15):5333-9.
产品手册
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