IXA4
CAS No. 1185329-96-7
IXA4 ( —— )
产品货号. M28621 CAS No. 1185329-96-7
IXA4 是 IRE1/XBP1 的高选择性、无毒激活剂,通过激活 IRE1 减少 APP 分泌。 IXA4 刺激的 IRE1 激活也增强了胰腺功能。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥648 | 有现货 |
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10MG | ¥1037 | 有现货 |
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25MG | ¥1361 | 有现货 |
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50MG | ¥2195 | 有现货 |
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100MG | ¥3524 | 有现货 |
|
200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
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生物学信息
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产品名称IXA4
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述IXA4 是 IRE1/XBP1 的高选择性、无毒激活剂,通过激活 IRE1 减少 APP 分泌。 IXA4 刺激的 IRE1 激活也增强了胰腺功能。
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产品描述IXA4 is a highly selective, nontoxic activator of IRE1/XBP1s and reduces APP secretion by activating IRE1. IXA4-stimulated IRE1 activation also enhanced pancreatic function.(In Vitro):In other cell lines including Huh7 and SHSY5Y cells, IXA4 selectively upregulated XBP1s mRNA relative to genes regulated by ATF6 (eg BiP) or PERK (eg CHOP). IXA4 reduces Aβ levels by 50% in conditioned medium prepared on CHO7PA2 cells expressing the V717F APP (APPV717F) mutant . IXA4 rescues mitochondrial defects in SH-SY5Y cells expressing disease-associated APP mutants. After 4 h of treatment in HEK293T cells, IXA4 promotes adaptive IRE1/XBP1s signaling, but not RIDD . IXA4 also promotes selective transcriptional remodeling of the ER proteostasis pathway relative to the cytoplasmic or mitochondrial pathway.
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体外实验IXA4 (10 μM; 4 hours) selectively upregulates XBP1s mRNA, relative to genes regulated by ATF6 (e.g., BiP) or PERK (e.g., CHOP), in other cell lines including Huh7 and SHSY5Y cells. IXA4 (10μM; 18 hours) reduces Aβ levels 50% in conditioned media prepared on CHO7PA2 cells expressing the V717F APP (APPV717F) mutant. IXA4 rescues mitochondrial defects in SH-SY5Y cells expressing disease-relevant APP mutants. IXA4 (10μM; 4 hours) promotes adaptive IRE1/XBP1s signaling, but not RIDD, following 4 hrs of treatment in HEK293T cells.IXA4 also promotes selective transcriptional remodeling of ER proteostasis pathways, relative to cytosolic or mitochondrial pathways.
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体Calcium channel
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研究领域——
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适应症——
化学信息
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CAS Number1185329-96-7
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分子量436.5
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分子式C24H28N4O4
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 100 mg/mL (229.10 mM)
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SMILESCc(cc1)ccc1OCCN(C)C(Cn1ncc(NC(CCOc2ccccc2)=O)c1)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.TakashiYamamoto, et al. Discovery, structure-activity relationship study, and oral analgesic efficacy of cyproheptadine derivatives possessing N-type calcium channel inhibitory activity. Bioorg Med Chem. 2006 Aug 1;14(15):5333-9.
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