IU-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

IU-1 (USP14 inhibitor IU1) is a specific, small molecule inhibitor of deubiquitinating enzyme USP14 with IC50 of 4-5 uM.

IU-1 (USP14 inhibitor IU1) is a specific, small molecule inhibitor of deubiquitinating enzyme USP14 with IC50 of 4-5 uM; displays no activity against other human eight DUBs (Uch37, Uch-L1/L3, USP7, etc.); enhances proteasomal degradation in vivo, attenuates cerebral ischemia/reperfusion-induced neuronal injury in mice; also inhibits Dengue virus replication.

USP14 inhibitor IU1

Proteasome/Ubiquitin

DUB

USP14

Cancer

——

314245-33-5

300.38

C18H21FN2O

>98% (HPLC)

DMSO: 30 mg/mL (100 mM); Ethanol: 15 mg/mL (50 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )

CC1=CC(C(CN2CCCC2)=O)=C(C)N1C3=CC=C(F)C=C3

1-[1-(4-fluorophenyl)-2,5-dimethylpyrrol-3-yl]-2-pyrrolidin-1-ylethanone

(-20℃)

With Ice Pack

≥ 2 years