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ISA27
CAS No. 1254366-73-8
ISA27 ( ISA 27 )
产品货号. M11032 CAS No. 1254366-73-8
ISA27 是一种新型小分子，可阻断 p53-MDM2 相互作用并在体外和体内诱导细胞凋亡。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称ISA27
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述ISA27 是一种新型小分子，可阻断 p53-MDM2 相互作用并在体外和体内诱导细胞凋亡。
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产品描述ISA27 is a novel small molecule that blocks p53-MDM2 interaction and induces apoptosis both in vitro and in vivo; reduces cell proliferation and induces apoptosis in vitro in cells carrying either p53 WT or mutated gene, suggesting that its effect is independent from p53 transcriptional activity; induces cancer cell death in a dose-dependent manner through the activation of the mitochondrial-dependent death signalling in p53-mutated cells.
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体外实验——
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体内实验——
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同义词ISA 27
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通路Apoptosis
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靶点MDM2-p53
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受体MDM2-p53
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研究领域——
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适应症——
化学信息
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CAS Number1254366-73-8
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分子量399.849
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分子式C19H14ClN3O3S
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纯度>98% (HPLC)
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溶解度——
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SMILES——
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化学全称(3R,7aR)-6-(4-chlorobenzyl)-1H-spiro[imidazo[1,5-c]thiazole-3,3'-indoline]-2',5,7(6H,7aH)-trione
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Sorriento D, et al. Br J Cancer. 2015 Jan 6;112(1):77-85.
