AM-7209

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种有效且选择性的 MDM2-p53 相互作用抑制剂，Kd 为 38 pM，IC50 为 1.6 nM。

A potent and selective inhibitor of the MDM2-p53 interaction with Kd of 38 pM, and IC50 of 1.6 nM; potently inhibits cell growth on-target in the tumor cell line with wild-type p53 cell with IC50 of 2 nM, exhibits >12,500-fold selectivity over those with p53-deficient cells; demonstrates remarkable pharmacokinetic properties and in vivo antitumor activity in both the SJSA-1 osteosarcoma xenograft model (ED50=2.6 mg/kg QD) and the HCT-116 colorectal carcinoma xenograft model (ED50=10 mg/kg QD).

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AM 7209 | AM7209

Apoptosis

MDM2-p53

MDM2-p53

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1623432-51-8

747.7

C37H41Cl2FN2O7S

>98% (HPLC)

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O=C(O)C1=CC=C(NC(C[C@]2(C)C(N([C@@H](C3CC3)CS(=O)(C(C)(C)C)=O)[C@H](C4=CC=C(Cl)C(F)=C4)[C@@H](C5=CC=CC(Cl)=C5)C2)=O)=O)C=C1OC

4-(2-((3R,5R,6S)-1-((S)-2-(tert-Butylsulfonyl)-1-cyclopropylethyl)-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3- methyl-2-oxopiperidin-3-yl)acetamido)-2-methoxybenzoic Acid

(-20℃)

With Ice Pack

≥ 2 years