IQ3

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

IQ3 是 JNK3（JNK3、JNK1 和 JNK2，Kd 分别为 66 nM、240 nM 和 290 nM）的选择性抑制剂。

IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 μM, also inhibits TNF-α and IL-6 production in vitro.

IQ-3 exhibits IC50 of 2.2 μM (TNF-α in human monoMac-6 cells), 1.5 μM (IL-6 in human monoMac-6 cells), 4.7 μM (TNF-α in human PBMCs), 9.1 μM (IL-6 in human PBMCs) and 6.1 μM (NO in murine J774.A1), respectively.IQ-3 exhibits an IC50 of 1.4 μM for inhibiting LPS-induced NF-κB/AP-1 transcriptional activity in human THP-1 Blue monocytic cells.IQ-3 is indeed a competitive inhibitor for the ATP binding site of JNK3. Cell Viability Assay Cell Line:PBMCs.Concentration:0-80 μM (200 ng/mL LPS).Incubation Time:30 min.Result:Downregulated TNF-α concentration (IC50 = 4.7 μM).

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MAPK/ERK Signaling

JNK

JNK3|JNK1|JNK2

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312538-03-7

341.32

C20H11N3O3

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (73.25 mM)

O=C(ON=C1C2=CC=CC=C2C2=NC3=CC=CC=C3N=C12)C1=CC=CO1

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(-20℃)

With Ice Pack

≥ 2 years