JNK
JNKs are a part of the superfamily of mitogen-activated protein kinases that heavily influence both cell proliferation and apoptosis, where the activation of JNKs can result in either proliferation or apoptosis, depending on the type of stimuli and/or cell type. One route through which JNKs influence extrinsic apoptosis initiation is through TNF interactions. Specifically, JNKs have been shown to be activated by TNFα, and JNKs can also contribute to TNF-induced apoptosis. JNK is also involved in intrinsic apoptosis initiation, where for instance, JNKs have been shown to induce the transcription of proapoptotic genes through direct transcriptional activity or through specific transcription factors, such as c-Jun. Additionally, JNK can mediate the expression of Bcl-2 family members. The JNK pathway therefore plays a large role in the regulation of both extrinsic and intrinsic apoptosis initiation pathways.
MAPK/ERK Signaling
JNK
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AS601245.2TFA (345987-15-7 free base)
产品货号 : M37587
cas no: 345987-16-8
AS601245.2TFA (345987-15-7 free base) (AS601245.2TFA) is a cell-permeable Inhibitor of JNK (IC50s of 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectively). -
JNK-IN-13
产品货号 : M37058
cas no: 345986-38-1
JNK-IN-13 (compound 1) 是一种有效的选择性 JNK 抑制剂,对 JNK3 和 JNK2 的 IC50 值分别为 290 nM 和 500 nM。 -
BSJ-04-122
产品货号 : M36505
cas no: 2513289-74-0
BSJ-04-122 是一种共价 MKK4/7 双重抑制剂。BSJ-04-122 抑制 MKK4 和 MKK7,IC50 值分别为 4 nM 和 181 nM。BSJ-04-122 可用于癌症研究。 -
JNK-IN-11
产品货号 : M35433
cas no: 676594-38-0
JNK-IN-11 (compound 1) 是一种有效的 JNK 抑制剂,对 JNK1、JNK2、JNK3 的 IC50 值分别为 1.8、21.4、2.2 μM。JNK-IN-11 具有研究阿尔茨海默病和帕金森病的潜力。 -
SP 600125, negative control
产品货号 : M35021
cas no: 54642-23-8
SP 600125, negative control (SPM1) 是一种吡唑蒽酮的烷基衍生物,可作为SP600125 (HY-12041) 的阴性对照。