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INX-08189
CAS No. 1234490-83-5
INX-08189 ( INX08189;BMS-986094 )
产品货号. M10937 CAS No. 1234490-83-5
A phosphoramidate prodrug of O-6-methyl-2-C-methyl guanosine, potent inhibitor of HCV NS5B polymerase with IC50 of 10 nM in replicon assay.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 50MG | ￥5775 | 有现货 |
|
| 100MG | ￥10044 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称INX-08189
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A phosphoramidate prodrug of O-6-methyl-2-C-methyl guanosine, potent inhibitor of HCV NS5B polymerase with IC50 of 10 nM in replicon assay.
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产品描述A phosphoramidate prodrug of O-6-methyl-2-C-methyl guanosine, potent inhibitor of HCV NS5B polymerase with IC50 of 10 nM in replicon assay; inhibits viral replication with EC50 of 35 nM, inhibits mutant NS5b S282T mutant replicon with EC90 of 344 nM; orally active.HCV Infection Phase 2 Discontinued
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同义词INX08189;BMS-986094
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通路Microbiology/Virology
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靶点HCV
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受体HCV
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研究领域Infection
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适应症HCV Infection
化学信息
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CAS Number1234490-83-5
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分子量658.65
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分子式C30H39N6O9P
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESC[C@H](NP(OC1=C2C=CC=CC2=CC=C1)(OC[C@H]3O[C@@H](N4C=NC5=C(OC)N=C(N)N=C45)[C@](C)(O)[C@@H]3O)=O)C(OCC(C)(C)C)=O
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化学全称Neopentyl ((((2R,3R,4R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(naphthalen-1-yloxy)phosphoryl)-L-alaninate
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. McGuigan C, et al. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4850-4.
2. Vernachio JH, et al. Antimicrob Agents Chemother. 2011 May;55(5):1843-51.
3. Ehteshami M, et al. Antimicrob Agents Chemother. 2016 Jul 22;60(8):4659-69.
2. Vernachio JH, et al. Antimicrob Agents Chemother. 2011 May;55(5):1843-51.
3. Ehteshami M, et al. Antimicrob Agents Chemother. 2016 Jul 22;60(8):4659-69.
产品手册
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