INDY

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

INDY 是 Dyrk1A 和 Dyrk1B 的 ATP 竞争性抑制剂，Dyrk1A ATP 口袋的 IC50 分别为 0.24 μM 和 0.23 μM，Ki 为 0.18 μM。

INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.(In Vitro):INDY effectively rescues the repressed NFAT signaling induced by Dyrk1A overexpression. In COS7 cells transfected with either EGFP-Dyrk1A or EGFP-tau, INDY mildly inhibits tau-phosphorylation at the dose of 3 μM, and inhibits nearly completely at the dose of 30 μM.(In Vivo):In the Xenopus embryo, ProINDY (2.5 μM) recoveres normal development apparently.

Western Blot Analysis Cell Line:COS7 cells transfected with either EGFP-Dyrk1A and EGFP-tau Concentration:0.3, 1, 3, 10, 30 μM Incubation Time:20 hours Result:Mildly inhibited tau-phosphorylation at 3 μM, and nearly completely inhibited at 30 μM.

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-(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one

Others

Other Targets

GluN1| NMDA receptor

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1169755-45-6

235.3

C12H13NO2S

>98% (HPLC)

In Vitro:?DMSO : ≥ 33.33 mg/mL (141.65 )

CCN1\C(Sc2ccc(O)cc12)=C\C(C)=O

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(-20℃)

With Ice Pack

≥ 2 years