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IMR-1A

CAS No. 331862-41-0

IMR-1A ( IMR-1A; IMR 1A; Inhibitor of Mastermind Recruitment-1 Acid )

产品货号. M17483 CAS No. 331862-41-0

IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.

纯度: 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥2001 有现货
10MG ¥2989 有现货
25MG ¥5038 有现货
50MG ¥7169 有现货
100MG ¥9639 有现货
500MG ¥19683 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    IMR-1A
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.
  • 产品描述
    IMR-1A is a metabolite of IMR-1. IMR-1A acts as Notch inhibitor and targeting gene transcription by disrupting Mam1 recruitment to chromatin.
  • 同义词
    IMR-1A; IMR 1A; Inhibitor of Mastermind Recruitment-1 Acid
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Notch
  • 研究领域
    Cancer
  • 适应症
    ——

化学信息

  • CAS Number
    331862-41-0
  • 分子量
    325.36
  • 分子式
    C13H11NO5S2
  • 纯度
    98%
  • 溶解度
    DMSO : ≥ 31 mg/mL; 95.28 mM
  • SMILES
    O=C(O)COc1ccc(/C=C/2\SC(=S)NC2=O)cc1OC
  • 化学全称
    2-[2-Methoxy-4-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]phenoxy]acetic acid

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Astudillo L,et al. The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res. 2016 Jun 15;76(12):3593-603.
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