
Ciproxifan
CAS No. 184025-18-1
Ciproxifan ( FUB-359 )
产品货号. M17394 CAS No. 184025-18-1
Ciproxifan 是一种高效且特异性的组胺 H3 受体拮抗剂 (IC50: 9.2 nM)。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥405 | 有现货 |
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5MG | ¥599 | 有现货 |
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10MG | ¥915 | 有现货 |
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25MG | ¥1912 | 有现货 |
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50MG | ¥3426 | 有现货 |
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100MG | 获取报价 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Ciproxifan
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Ciproxifan 是一种高效且特异性的组胺 H3 受体拮抗剂 (IC50: 9.2 nM)。
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产品描述Ciproxifan is a highly effective and specific histamin H3-receptor antagonist (IC50: 9.2 nM).
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体外实验Ciproxifan inhibits [3H]HA release from synaptosomes of rat cerebral cortex, with a Ki of 0.5 nM.Ciproxifan (0.01 nM-1 μM; 60 min) inhibits the binding of [125I]iodoproxyfan with rat striatal membranes, with a Ki of 0.7 nM.
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体内实验Ciproxifan (1 mg/kg; a single p.o.) increases the t-MeHA level in mouse brain, with an ED50 of 0.14 mg/kg.Ciproxifan (3 mg/kg, i.p.) improves the accuracy of responding in the five-choice task in rats only when the stimulus duration was 0.25 sec instead of 0.50 sec.Ciproxifan (0.15-2 mg/kg; p.o.) induces marked signs of neocortical electroencephalogram activation manifested by enhanced fast-rhythms density and an almost total waking state in cats.Ciproxifan (1 mg/kg; a single i.v.) decreases the H3-receptor ligand concentration in serum in mice, with the half-lives (t1/2) of 13 and 87 min for the distribution and elimination phases in mice, respectively.Ciproxifan (1 mg/kg; a single p.o.) exhibits oral bioavailability (F=62%) and maximal concentration (Cmax=420 nM) in mice.
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同义词FUB-359
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通路Others
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靶点Other Targets
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受体H3 receptor
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研究领域Neurological Disease
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适应症——
化学信息
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CAS Number184025-18-1
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分子量386.4
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分子式C16H18N2O2·C4H4O4
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纯度>98% (HPLC)
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溶解度——
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SMILESC1CC1C(=O)c1ccc(cc1)OCCCc1cnc[nH]1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Ligneau X, et al. J Pharmacol Exp Ther, 1998, 287(2), 658-666.
产品手册




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