IMB-301

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

IMB-301 (NSC 301209) 是一种小分子抑制剂，针对 HIV-1 Vif/hA3G 复合物的结合界面。

IMB-301 (NSC 301209) is a small molecule inhibitor that target the binding interface of the HIV-1 Vif/hA3G complex, inhibits the replication of HIV-1 in H9 cells (IC50=8.63 uM); restores hA3G expression in the presence of Vif through disruption of the Vif-hA3G interaction, significantly increases the amount of hA3G-HA in the virions; directly binds to hA3G with of 15.6 uM.

IMB-301 is able to increase virion encapsidation of hA3G via its ability to impair the degradation of hA3Gby Vif, which results in hA3G-dependent anti-HIV activity. IMB-301 binds to hA3G, restores hA3G expression in the presence of Vif, and inhibits the replication of HIV-1 in a hA3G-dependent manner.

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IMB301 | NSC 301209

Microbiology/Virology

HIV

HIV

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64009-84-3

379.256

C19H17Cl2FN2O

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (263.67 mM)

C1=CC(=CC=C1OCCC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)F

1-(2-(2,4-dichlorophenyl)-4-(4-fluorophenoxy)butyl)-1H-imidazole

(-20℃)

With Ice Pack

≥ 2 years