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IM156
CAS No. 1422365-93-2
IM156 ( —— )
产品货号. M22096 CAS No. 1422365-93-2
IM156 是一种口服生物可利用的线粒体氧化磷酸化 (OxPhos) 抑制剂，具有潜在的抗肿瘤活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥616 | 有现货 |
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| 10MG | ￥988 | 有现货 |
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| 25MG | ￥1604 | 有现货 |
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| 50MG | ￥3013 | 有现货 |
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| 100MG | ￥5038 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称IM156
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述IM156 是一种口服生物可利用的线粒体氧化磷酸化 (OxPhos) 抑制剂，具有潜在的抗肿瘤活性。
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产品描述IM156 is an orally bioavailable mitochondrial oxidative phosphorylation (OxPhos) inhibitor, with potential antineoplastic activity. IM156, a new metformin derivative, formerly known as HL156A, has been reported to ameliorate various types of fibrosis and inhibit in vitro and in vivo tumors by inducing AMPK activation more potently than metformin.?In vivo treatment of IM156 exacerbated the memory differentiation of virus-specific CD8+ T cells, resulting in an increase in short-lived effector cells but decrease in memory precursor effector cells.?Thus, IM156 treatment impaired the function of virus-specific memory CD8+ T cells, indicating that excessive AMPK activation weakens memory T cell differentiation, thereby suppressing recall immune responses.
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体外实验——
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体oxidative phosphorylation (OXPHOS)
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研究领域——
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适应症——
化学信息
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CAS Number1422365-93-2
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分子量315.13
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分子式C13H16F3N5O?
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纯度>98% (HPLC)
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溶解度——
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SMILESFC(F)(F)Oc1ccc(NC(=N)NC(=N)N2CCCC2)cc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Son J , Cho Y W , Woo Y J , et al. Metabolic Reprogramming by the Excessive AMPK Activation Exacerbates Antigen-Specific Memory CD8 + T Cell Differentiation after Acute Lymphocytic Choriomeningitis Virus Infection[J]. Immune Network, 2019, 19(2).
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