AA147 ( ATF6-activator-147 )

产品货号. M22642 CAS No. 393121-74-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

拼团产品询价大包装询价加入购物车

产品名称

AA147
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

AA147 is a small molecule endoplasmic reticulum (ER) proteostasis regulator.?The selectively activates ATF6 arm of the unfolded protein response (UPR) .
产品描述

AA147 is a small molecule endoplasmic reticulum (ER) proteostasis regulator.?The selectively activates ATF6 arm of the unfolded protein response (UPR) .It acts as a prodrug that preferentially triggers ATF6 signaling through a mechanism involving localized metabolic activation and selective covalent modification of ER resident proteins that regulate ATF6 activity.
同义词

ATF6-activator-147
通路

Others
靶点

Other Targets
受体

ATF6
研究领域

——
适应症

——

1. Christina COOLEY, et al. Regulators of the endoplasmic reticulum proteostasis network. WO2017117430A1.

计算器

产品手册

关联产品

7,2,4-Trihydroxy-5-m...

7,2',4'-Trihydroxy-5-methoxy-3-arylcoumarin shows activity in inhibiting prostate specific antigen (PSA) secreted from androgen dependent prostate cancer cell line, LNCaP cells.
Cirsimaritin

Cirsimaritin exhibits antibacterial, anti-inflammation, anti-tumor, antioxidant properties and renal protection. Cirsimaritin binds weakly to the benzodiazepine site on GABAA receptors.
Methyl nomilinate

Methyl nomilinate from citrus can modulate cell cycle regulators to induce cytotoxicity in human colon cancer (SW480) cells in vitro.