IDH889 ( —— )

产品货号. M26714 CAS No. 1429179-07-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

IDH889
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

IDH889 is a brain penetrant, an allosteric and mutant specific IDH1 inhibitor. IDH889 has effective selectivity for IDH1 R132* mutations (IC50s: 0.02 μM, 0.072 μM, and 1.38 μM for IDH1R132H, IDH1R132C, and IDH1wt).
产品描述

IDH889 is a brain penetrant, an allosteric and mutant specific IDH1 inhibitor. IDH889 has effective selectivity for IDH1 R132* mutations (IC50s: 0.02 μM, 0.072 μM, and 1.38 μM for IDH1R132H, IDH1R132C, and IDH1wt).(In Vitro):IDH889 displays effective cellular inhibition of R-2-hydroxyglutarate (2-HG) production (IC50: 0.014 μM).
同义词

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通路

Metabolic Enzyme/Protease
靶点

Dehydrogenase
受体

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研究领域

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适应症

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1.Toskes PP, et al. The bentiromide test for pancreatic exocrine insufficiency. Pharmacotherapy. 1984 Mar-Apr;4(2):74-80.

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