IDF-11774 ( IDF 11774 | IDF11774 )

产品货号. M11810 CAS No. 1429054-28-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

IDF-11774
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

IDF-11774 (IDF 11774, IDF11774) 是一种有效的、口服生物可利用的 HIF-1 抑制剂。
产品描述

IDF-11774 (IDF 11774, IDF11774) is a potent, orally bioavailable HIF-1 inhibitor that reduces the HRE-luciferase activity of HIF-1α (IC50=3.65 uM) and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells; suppresses the mRNA expression of HIF-1 target genes VEGF and EPO but not HIF-1α; inhibits the accumulation of HIF-1α in vitro and in vivo in colorectal carcinoma HCT116 cells; exhibits substantial anticancer efficacy in mouse models containing KRAS, PTEN, or VHL mutations.
体外实验

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体内实验

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同义词

IDF 11774 | IDF11774
通路

Angiogenesis
靶点

HIF/HIF Prolyl-hydroxylase
受体

HIF/HIF Prolyl-hydroxylase
研究领域

Cancer
适应症

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CAS Number

1429054-28-3
分子量

368.521
分子式

C23H32N2O2
纯度

>98% (HPLC)
溶解度

DMSO : 60 mg/mL 162.82 mM
SMILES

O=C(N1CCN(C)CC1)COC2=CC=C(C34C[C@H]5C[C@@](C4)([H])C[C@H](C5)C3)C=C2
化学全称

2-(4-((3r,5r,7r)-adamantan-1-yl)phenoxy)-1-(4-methylpiperazin-1-yl)ethan-1-one