KHS-101 ( KHS101 )

产品货号. M11097 CAS No. 1262770-73-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

KHS-101
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

KHS-101 (KHS101) 是一种小分子，可选择性诱导神经元分化表型。
产品描述

KHS-101 (KHS101) is a small molecule that selectively induces a neuronal differentiation phenotype, induces neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs) by interacting with TACC3 (EC50=1 uM); works indirectly on HIF complex formation by destabilizing both TACC3 and the HIF component HIF-1α, decreases TACC3 levels in cells and regulates HIF gene expression; significantly increases neuronal differentiation in rats in vivo.
体外实验

RT-PCRCell Line:Rat NPCs Concentration:0.6, 1.7 and 5 μM Incubation Time:24 h Result:Showed a dose-dependent induction of Cdkn1 mRNA expression.Cell Proliferation Assay Cell Line:Rat NPCs Concentration:5 μM Incubation Time:24, 48 and 72 h Result:The vast majority of NPCs stop proliferating within 72 h, become mitotically inactive.
体内实验

Animal Model:Adult Fisher 344 rats (～10 wk old) Dosage:6 mg/kg Administration:SC, BID for 14 days Result:Increased neuronal differentiation. Reduced proliferation of NPCs.
同义词

KHS101
通路

Angiogenesis
靶点

HIF/HIF Prolyl-hydroxylase
受体

TACC3
研究领域

——
适应症

——

CAS Number

1262770-73-9
分子量

339.46
分子式

C18H21N5S
纯度

>98% (HPLC)
溶解度

DMSO: 15 mg/mL; Ethanol: 15 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

CC(C)CNC1=NC(=NC=C1)NCC2=CSC(=N2)C3=CC=CC=C3
化学全称

N4-isobutyl-N2-((2-phenylthiazol-4-yl)methyl)pyrimidine-2,4-diamine

1. Wurdak H, et al. Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16542-7. 2. Guo Y, et al. ACS Chem Biol. 2013 Mar 15;8(3):626-35.

计算器

产品手册

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