I-BRD9 ( I-BRD9; I-BRD-9; I-BRD 9 )

产品货号. M12612 CAS No. 1714146-59-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

拼团产品询价大包装询价加入购物车

产品名称

I-BRD9
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

The first selective cellular chemical probe for BRD9 with pIC50 of 7.3.
产品描述

The first selective cellular chemical probe for BRD9 with pIC50 of 7.3; displays 700-fold selectivity over the BET family and 200-fold over the highly homologous BRD7; decreases cell proliferation, G1-arrest and apoptosis in rhabdoid tumor cells; shows synergistic inhibitory effects on cell proliferation combined with doxorubicin or carboplatin.
同义词

I-BRD9; I-BRD-9; I-BRD 9
通路

Chromatin/Epigenetic
靶点

Bromodomain
受体

BRD4;BRD9
研究领域

Other Indications
适应症

——

CAS Number

1714146-59-4
分子量

497.55
分子式

C22H22F3N3O3S2
纯度

>98% (HPLC)
溶解度

DMSO: 15.5 mg/mL
SMILES

N=C(C(S1)=CC2=C1C(C3=CC=CC(C(F)(F)F)=C3)=CN(CC)C2=O)NC(CC4)CCS4(=O)=O
化学全称

Thieno[3,2-c]pyridine-2-carboximidamide, 5-ethyl-4,5-dihydro-4-oxo-N-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)-7-[3-(trifluoromethyl)phenyl]-

1. Theodoulou NH, et al. J Med Chem. 2016 Feb 25;59(4):1425-39.
2. Krmer KF, et al. Int J Mol Sci. 2017 Jul 16;18(7). pii: E1537.

计算器

产品手册

关联产品

SGC-iMLLT

SGC-iMLLT is the first small molecule chemical probe for the YD of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3) with Kd of 129 and 77 nM respectively.
CPI-268456

A bromodomain-containing protein inhibitor.
CN427

CN427 (CN-427) is novel BRD4 (BD1, 2) inhibitor with IC50 of 66 nM, MV4-11 viability IC50 of 1.1 uM.