Hydrangenol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

绣球酚是从绣球花叶子中分离出来的，在体外具有抗光老化活性。

Hydrangenol is isolated from Hydrangea serrata leaves exerts antiphotoaging activity in vitro.(In Vitro):Hydrangenol increased the expression of involucrin, filaggrin, and aquaporin-3 (AQP3) as well as hyaluronic acid (HA) production via hyaluronidase (HYAL)-1/-2 downregulation. Consistent with the recovery of collagen composition, the expression of Pro-COL1A1 was increased by hydrangenol.

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Animal Model:UVB-irradiated HR-1 hairless miceDosage:5, 10, 20, or 40 mg/kg Administration:Oral gavage; daily for 7 weeksResult:Increased the expression of involucrin, filaggrin, and aquaporin-3 (AQP3) as well as hyaluronic acid (HA) production via hyaluronidase (HYAL)-1/-2 downregulation. Increased the expression of Pro-COL1A1.Decreased the expression matrix metalloproteinase (MMP)-1/-3, cyclooxygenase-2 (COX-2), and interleukin-6 (IL-6).Attenuated the phosphorylation of mitogen-activated protein kinases (MAPKs) including ERK and p38, activator protein 1 (AP-1) subunit, and signal transduction and activation of transcription 1 (STAT1).Upregulated the expression of nuclear factor-E2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), NAD(P)H quinone dehydrogenase 1 (NQO-1), glutamate cysteine ligase modifier subunit (GCLM), and glutamate cysteine ligase catalysis subunit (GCLC).

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Immunology/Inflammation

NOS

NOS

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480-47-7

256.3

C15H12O4

>98% (HPLC)

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Oc1ccc(cc1)C1Cc2cccc(O)c2C(=O)O1

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(-20℃)

With Ice Pack

≥ 2 years