Hexylresorcinol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Hexylresorcinol (4-Hexylresorcinol) 是在植物中发现的一种天然化合物，具有抗菌、驱虫、防腐和抗肿瘤活性。Hexylresorcinol 可诱导鳞癌细胞凋亡 (apoptosis)。Hexylresorcinol 是一种可逆、非竞争性的 α-葡萄糖苷酶 (α-glucosidase) 抑制剂。Hexylresorcinol 具有抗 DNA 氧化损伤的保护作用。

Hexylresorcinol is an organic compound with local anaesthetic, antiseptic and anthelmintic properties, is a potent inhibitor of mushroom tyrosinase, causing 90% loss of activity at 100 μM.(In Vitro):Hexylresorcinol potently inhibits Gram positive bacteria, with MICs of 20-50 mg/L for several Gram positive bacteria. Gram negative bacteria, yeasts and fungi are less sensitive to it.Hexylresorcinol inhibits oxidative DNA damage in human lymphocytes by increasing levels of glutathione and modulation of antioxidant enzymes (GPX, GR and GST).Hexylresorcinol (1-10 μg/mL; 24-72 hours) suppresses squamous carcinoma cell line SCC-9 proliferation.Hexylresorcinol has strong antitumor effects by inhibiting calcium channel oscillation and inducing apoptosis.Hexylresorcinol upregulates TGF-β/SMAD/VEGF signaling in endothelial cells and induces vascular regeneration and remodeling for wound healing.(In Vivo):Hexylresorcinol (10 mg/kg; i.p.; daily; for 16 days) inhibits tumor cell proliferation in mouse tumor xenografts and concomitant application of calcium channel blocker partly reverses the antitumor effect of Hexylresorcinol.

Hexylresorcinol potently inhibits Gram positive bacteria, with MICs of 20-50 mg/L for several Gram positive bacteria. Gram negative bacteria, yeasts and fungi are less sensitive to it.Hexylresorcinol inhibits oxidative DNA damage in human lymphocytes by increasing levels of glutathione and modulation of antioxidant enzymes (GPX, GR and GST).Hexylresorcinol (1-10 μg/mL; 24-72 hours) suppresses squamous carcinoma cell line SCC-9 proliferation.Hexylresorcinol has strong antitumor effects by inhibiting calcium channel oscillation and inducing apoptosis.Hexylresorcinol upregulates TGF-β/SMAD/VEGF signaling in endothelial cells and induces vascular regeneration and remodeling for wound healing. Cell Proliferation Assay Cell Line:SCC-9 cells Concentration:1 μg/mL, 5 μg/mL, 10 μg/mL Incubation Time:24 hours, 48 hours, 72 hours Result:Inhibited SCC-9 cells proliferation.Apoptosis AnalysisCell Line:SCC-9 cells Concentration:10 μg/mL Incubation Time:24 hours Result:Induced morphological and biochemical changes in SCC-9 cells.

Hexylresorcinol (10 mg/kg; i.p.; daily; for 16 days) inhibits tumor cell proliferation in mouse tumor xenografts and concomitant application of calcium channel blocker partly reverses the antitumor effect of Hexylresorcinol. Animal Model:Male nude mice (BALB/cAnNCrj-nu/nu), with SCC-9 cells xenograft Dosage:10 mg/kg Administration:Intraperitoneal injection, daily, for 16 days Result:Reduced tumor formation in vivo.

Hexylresorcinol | Ascaricid | Ascarinol | Ascaryl | NSC 1570

Proteasome/Ubiquitin

Tyrosinase

diphenolase| monophenolase

Other Indications

——

136-77-6

194.27

C12H18O2

>98% (HPLC)

Water: 500 mg/L at 18 °C.

OC1=CC=C(CCCCCC)C(O)=C1

4-Hexylresorcinol

(-20℃)

With Ice Pack

≥ 2 years