Tyrosinase
Tyrosinase (monophenol or o-diphenol, oxygen oxidoreductase, syn.polyphenol oxidase), a multifunctional membrane bound type-3 copper-containing glycoprotein is located in the membrane of the melanosome.Tyrosinase is also catalyzing the process of neuromelanin production in which the oxidation of dopamine produces dopaquinones. Tyrosinase is also catalyzing the process of neuromelanin production in which the oxidation of dopamine produces dopaquinones. Excessive production of dopaquinones results in neuronal damage and cell death. In animals, the tyrosinase family of proteins is composed of three members, the authentic tyrosinase and two other related proteins, named Trp1 and Trp2.
The three members of the family show a common architecture of the tridimensional structure, and the three proteins are anchored to the melanosomal membrane through a C-terminal fragment. The intramelanosomal domains of the three proteins are similar in length, and they contain a binuclear metal ion-binding motif with six conserved His. However, the C-terminal tails show very low homology, and they were used to generate specific antibodies, PEP1, PEP7 and PEP8 for Trp1, tyrosinase and Trp2, respectively. The specific reactivity of those antibodies against each C-tail allowed the differentiation, characterization and quantitation of the three proteins. Tyrosinase might play a significant role in neuromelanin formation in the human brain and responsible for the neurodegeneration associated with Parkinson’s disease and Huntington’s diseases.
References
1.Pillaiyar T, et al. J Enzyme Inhib Med Chem. 2017;32(1):403–425.
2.Solano F. Int J Mol Sci. 2018;19(2):633.
The three members of the family show a common architecture of the tridimensional structure, and the three proteins are anchored to the melanosomal membrane through a C-terminal fragment. The intramelanosomal domains of the three proteins are similar in length, and they contain a binuclear metal ion-binding motif with six conserved His. However, the C-terminal tails show very low homology, and they were used to generate specific antibodies, PEP1, PEP7 and PEP8 for Trp1, tyrosinase and Trp2, respectively. The specific reactivity of those antibodies against each C-tail allowed the differentiation, characterization and quantitation of the three proteins. Tyrosinase might play a significant role in neuromelanin formation in the human brain and responsible for the neurodegeneration associated with Parkinson’s disease and Huntington’s diseases.
References
1.Pillaiyar T, et al. J Enzyme Inhib Med Chem. 2017;32(1):403–425.
2.Solano F. Int J Mol Sci. 2018;19(2):633.
Proteasome/Ubiquitin
Tyrosinase
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(Z)-SU14813
产品货号 : M37572
cas no: 452105-23-6
(Z)-SU14813 is a novel tyrosine kinase inhibitor with anticardiogenic and antitumor activity that inhibits VEGFR-2, PDGFR-β, and FLT3 phosphorylation in xenograft tumors in a dose- and time-dependent manner. -
EGFR-IN-87
产品货号 : M37255
cas no: 1835666-87-9
EGFR-IN-87 是一种 EGFR 酪氨酸激酶抑制剂。EGFR-IN-87 对 A431 细胞中EGFR_d746-750, EGFR_L858R/T790 和 EGFR_WT 的 IC50 值分别为 3.1 nM, 1.3 nM 和 7.1 nM。EGFR-IN-87 可用于癌症疾病的研究。 -
Tyrosinase-IN-12
产品货号 : M37195
cas no: 1860779-42-5
Non-competitive tyrosinase inhibitor (Tyrosinase-IN-12) 是一种有效的,非竞争性抗氧化和 酪氨酸酶 抑制剂,其 IC50 值为49.33 ± 2.64 μM,Ki 值为31.25 ± 0.25 μM。Non-competitive tyrosinase inhibitor (Tyrosinase-IN-12) 有最高的自由基清除活性,减少活性氧 (ROS) 的产生,IC50 值为25.39 ± 0.77 μM。可用于食品和农业部门中抗褐变物质的研究。 -
hTYR/AbTYR-IN-1
产品货号 : M37018
cas no: 1625821-37-5
hTYR/AbTYR-IN-1 (Compound 7) 是一种 hTYR/AbTYR 双重抑制剂,对 hTYR 和 AbTYR 的 IC50 分别为 5.4 μM 和 3.52 μM。 -
Flanvotumab
产品货号 : M36794
cas no: 1188277-05-5
Flanvotumab (IMC-20D7S) 是一种靶向酪氨酸酶相关蛋白 (TYRP1) 的人源单克隆抗体,TYRP1 特异性表达于黑色素细胞和黑色素瘤细胞。Flanvotumab 通过自然杀伤介导的、抗体依赖的细胞介导的细胞毒作用 (ADCC) 而行使功能。Flanvotumab 具有较强的抗肿瘤活性和良好的耐受性。