
HPi1
CAS No. 13080-21-2
HPi1 ( —— )
产品货号. M23464 CAS No. 13080-21-2
HPi1 是一种选择性口服活性抗菌剂,针对幽门螺杆菌(IC50:0.24 μM,MIC 0.08-0.16 μg/mL)。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥316 | 有现货 |
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10MG | ¥518 | 有现货 |
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25MG | ¥932 | 有现货 |
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50MG | ¥1596 | 有现货 |
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100MG | ¥2252 | 有现货 |
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200MG | ¥3386 | 有现货 |
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500MG | ¥5524 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称HPi1
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述HPi1 是一种选择性口服活性抗菌剂,针对幽门螺杆菌(IC50:0.24 μM,MIC 0.08-0.16 μg/mL)。
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产品描述HPi1 is a selective and orally active antimicrobial against Helicobacter pylori (IC50: 0.24 μM and a MIC of 0.08-0.16 μg/mL). HPi1 is inactive against other Xaliproden, including the gut commensals, Lactobacillus reuteri, Lactobacillus casei, and Bifidobacterium longum.
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体外实验The MIC against H. pylori isolates ranged from 0.002-0.032 μg/mL (0.01-0.17 μM) in the agar dilution assay.HPi1 is effective against the clarithromycin-resistant strains ARHp172 (MIC of 0.004–0.016 μg/mL) and ARHp246 (MIC of 0.008–0.032 μg/mL). HPi1 has some activity against the Bacteroides species, but at concentrations at least 18-fold higher than the H. pylori MIC. More potent activity is detected for Campylobacter jejuni with an MIC of 0.3 μg/mL. HPi1 has good physicochemical and pharmacological properties, including determining the aqueous solubility (19 μg/mL), human plasma protein binding (93% bound), stability with human liver microsomes (T1/2 of 1.3 hours) and the ability to passively permeate membranes.
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体内实验HPi1 (6.25-50 mg/kg; Oral gavage; once a day; for 3 days; female C57BL/6 mice) treatment decreases colony counts below the limit of detection at doses of 25 or 50 mg/kg/day. Animal Model:Adult specific-pathogen-free female C57BL/6 mice (6-8-week-old) fed with H. pylori SS1 suspension Dosage:6.25 mg/kg, 12.5 mg/kg, 25 mg/kg, 50 mg/kg Administration:Oral gavage; once a day; for 3 days Result:Reduced colony counts to below the limit of detection.
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同义词——
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通路Others
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靶点Other Targets
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受体Helicobacter pylori
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研究领域——
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适应症——
化学信息
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CAS Number13080-21-2
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分子量192.24
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分子式C8H8N4S
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纯度>98% (HPLC)
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溶解度DMSO : 60 mg/mL?(312.11 mM;?Need ultrasonic)
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SMILESS=C1NC2=C(C=CC=C2)N=C1NN
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Gavrish E, et al. In vitro and in vivo activities of HPi1, a selective antimicrobial against Helicobacter pylori. Antimicrob Agents Chemother. 2014 Jun;58(6):3255-60.
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