
Taltirelin
CAS No. 103300-74-9
Taltirelin ( TA-0910 )
产品货号. M22035 CAS No. 103300-74-9
他替瑞林是促甲状腺素释放激素受体 (TRH-R) 超级激动剂(IC50 为 910 nM,EC50 为 36 nM,可刺激胞质 Ca2+ 浓度(Ca2+ 释放)增加。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥405 | 有现货 |
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10MG | ¥656 | 有现货 |
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50MG | ¥2552 | 有现货 |
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100MG | ¥4593 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Taltirelin
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述他替瑞林是促甲状腺素释放激素受体 (TRH-R) 超级激动剂(IC50 为 910 nM,EC50 为 36 nM,可刺激胞质 Ca2+ 浓度(Ca2+ 释放)增加。
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产品描述Taltirelin is at thyrotropin-releasing hormone receptor (TRH-R) superagonist (IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release))[1].Taltirelin (TAL), in mouse models of CRF.?To model fatigue, we used a mouse model of chemotherapy, a mouse model of radiation therapy, and mice bearing colon 26 carcinoma tumors.?We used the treadmill fatigue test to assess fatigue-like behavior after treatment with TAL.?Additionally, we used wild-type and TRH receptor knockout mice to determine which TRH receptor was necessary for the actions of TAL.?Tumor-bearing mice displayed muscle wasting and all models caused fatigue-like behavior, with mice running a shorter distance in the treadmill fatigue test than controls.?TAL reversed fatigue-like behavior in all three models and the mouse TRH1 receptor was necessary for the effects of TAL.?These data suggest that TAL may be useful in alleviating fatigue in all cancer patients and provide further support for evaluating TAL as a potential therapy for CRF in humans.
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体外实验——
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体内实验——
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同义词TA-0910
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通路Others
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靶点Other Targets
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受体Thyrotropin-releasing hormone receptor
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研究领域Nervous system
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适应症Spinocerebellar Degeneration
化学信息
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CAS Number103300-74-9
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分子量405.41
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分子式C17H23N7O5
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纯度>98% (HPLC)
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溶解度DMSO:30 mg/mL (74 mM)
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SMILESCN1C(=O)C[C@H](NC1=O)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N1CCC[C@H]1C(N)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Dougherty J P , Wolff B S , Cullen M J , et al. Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue.[J]. Pharmacological Research, 2017, 124:1-8.
产品手册




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