HDAC8-IN-20a

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

HDAC8-IN-20a is a potent, selective HDAC8 inhibitor with IC50 of 27 nM.

HDAC8-IN-20a is a potent, selective HDAC8 inhibitor with IC50 of 27 nM; efficiently blocks the activation of growth receptor survival signaling and shifts the cell cycle arrest and differentiation phenotype toward effective cell death of neuroblastoma cell lines combined with crizotinib, efficiently kills neuroblastoma cell lines carrying wildtype ALK, amplified ALK and those carrying the activating ALK F1174L mutation, as well as cells carrying the activating R1275Q mutation.

HDAC8-IN-20a; HDAC8 IN 20a; HDAC8IN20a; HDAC8 inhibitor-20a

Cell Cycle/DNA Damage

HDAC

HDAC

——

——

1884231-52-0

273.29

C15H15NO4

>98% (HPLC)

——

O=C(NO)C1=CC=C(OC)C(OCC2=CC=CC=C2)=C1

3-(benzyloxy)-N-hydroxy-4-methoxybenzamide

(-20℃)

With Ice Pack

≥ 2 years